Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial

Research output: Contribution to journalArticle

Abstract

Purpose: Neurofilament light (NfL) is a biomarker reflecting neurodegeneration and acute neuronal injury, and an increase is found following hypoxic brain damage. We assessed the ability of plasma NfL to predict outcome in comatose patients after out-of-hospital cardiac arrest (OHCA). We also compared plasma NfL concentrations between patients treated with two different targets of arterial carbon dioxide tension (PaCO2), arterial oxygen tension (PaO2), and mean arterial pressure (MAP). Methods: We measured NfL concentrations in plasma obtained at intensive care unit admission and at 24, 48, and 72 h after OHCA. We assessed neurological outcome at 6 months and defined a good outcome as Cerebral Performance Category (CPC) 1–2 and poor outcome as CPC 3–5. Results: Six-month outcome was good in 73/112 (65%) patients. Forty-eight hours after OHCA, the median NfL concentration was 19 (interquartile range [IQR] 11–31) pg/ml in patients with good outcome and 2343 (587–5829) pg/ml in those with poor outcome, p < 0.001. NfL predicted poor outcome with an area under the receiver operating characteristic curve (AUROC) of 0.98 (95% confidence interval [CI] 0.97–1.00) at 24 h, 0.98 (0.97–1.00) at 48 h, and 0.98 (0.95–1.00) at 72 h. NfL concentrations were lower in the higher MAP (80–100 mmHg) group than in the lower MAP (65–75 mmHg) group at 48 h (median, 23 vs. 43 pg/ml, p = 0.04). PaCO2 and PaO2 targets did not associate with NfL levels. Conclusions: NfL demonstrated excellent prognostic accuracy after OHCA. Higher MAP was associated with lower NfL concentrations.

Details

Authors
  • Lauri Wihersaari
  • Nicholas J. Ashton
  • Matti Reinikainen
  • Pekka Jakkula
  • Ville Pettilä
  • Johanna Hästbacka
  • Marjaana Tiainen
  • Pekka Loisa
  • Hans Friberg
  • Tobias Cronberg
  • Kaj Blennow
  • Henrik Zetterberg
  • Markus B. Skrifvars
  • the COMACARE STUDY GROUP
Organisations
External organisations
  • Kuopio University Hospital
  • Sahlgrenska Academy
  • Sahlgrenska University Hospital, Wallenberg Laboratory
  • King's College London
  • South London and Maudsley NHS Foundation Trust
  • Helsinki University Central Hospital
  • Päijät-Häme Central Hospital
  • Sahlgrenska University Hospital
  • Royal Free Hospital
  • University College London
  • Skåne University Hospital
  • University of Helsinki
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Anesthesiology and Intensive Care

Keywords

  • Biomarkers, Cardiac arrest, Neurofilament light (NfL), Prognostication
Original languageEnglish
Pages (from-to)39-48
JournalIntensive Care Medicine
Volume47
Issue number1
Early online date2020 Aug
Publication statusPublished - 2021
Publication categoryResearch
Peer-reviewedYes