Neuropsychological tests as discriminators between dementia of Alzheimer type and frontotemporal dementia

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T1 - Neuropsychological tests as discriminators between dementia of Alzheimer type and frontotemporal dementia

AU - Elfgren, C.

AU - Brun, A.

AU - Gustafson, L.

AU - Johanson, A.

AU - Minthon, L.

AU - Passant, U.

AU - Risberg, J.

PY - 1994/10/29

Y1 - 1994/10/29

N2 - The aim of this study was to examine whether cognitive test performance alone could distinguish patients with dementia of Alzheimer type (DAT) from those with frontotemporal dementia (FTD). Scores from three neuropsychological tests were used as discriminating variables in 28 cases with postmortem verified diagnoses. The selected tests measured verbal ability, visuospatial ability and verbal memory. Eighty-nine per cent of the sample was correctly classified by discriminant analysis. Evaluating the ability of the obtained discriminant function to differentiate between groups of DAT and FTD in a new, clinically diagnosed sample of 38 cases yielded an overall success rate of 84%. The results suggest that cognitive tests may be helpful for differential diagnosis in the context of a neuropsychiatric examination.

AB - The aim of this study was to examine whether cognitive test performance alone could distinguish patients with dementia of Alzheimer type (DAT) from those with frontotemporal dementia (FTD). Scores from three neuropsychological tests were used as discriminating variables in 28 cases with postmortem verified diagnoses. The selected tests measured verbal ability, visuospatial ability and verbal memory. Eighty-nine per cent of the sample was correctly classified by discriminant analysis. Evaluating the ability of the obtained discriminant function to differentiate between groups of DAT and FTD in a new, clinically diagnosed sample of 38 cases yielded an overall success rate of 84%. The results suggest that cognitive tests may be helpful for differential diagnosis in the context of a neuropsychiatric examination.

KW - adult

KW - aged

KW - Alzheimer disease

KW - article

KW - autopsy

KW - clinical article

KW - clinical trial

KW - cognition

KW - dementia

KW - depth perception

KW - differential diagnosis

KW - discriminant analysis

KW - female

KW - frontal lobe

KW - human

KW - male

KW - neuropsychological test

KW - task performance

KW - verbal behavior

KW - verbal memory

U2 - 10.1002/gps.930090807

DO - 10.1002/gps.930090807

M3 - Article

VL - 9

SP - 635

EP - 642

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 1099-1166

IS - 8

ER -