Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity

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Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity. / Barchetta, Ilaria; Cimini, Flavia Agata; Capoccia, Danila; Bertoccini, Laura; Ceccarelli, Valentina; Chiappetta, Caterina; Leonetti, Frida; Di Cristofano, Claudio; Silecchia, Gianfranco; Orho-Melander, Marju; Melander, Olle; Cavallo, Maria Gisella.

In: Nutrients, Vol. 10, No. 4, 526, 23.04.2018.

Research output: Contribution to journalArticle

Harvard

Barchetta, I, Cimini, FA, Capoccia, D, Bertoccini, L, Ceccarelli, V, Chiappetta, C, Leonetti, F, Di Cristofano, C, Silecchia, G, Orho-Melander, M, Melander, O & Cavallo, MG 2018, 'Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity', Nutrients, vol. 10, no. 4, 526. https://doi.org/10.3390/nu10040526

APA

Barchetta, I., Cimini, F. A., Capoccia, D., Bertoccini, L., Ceccarelli, V., Chiappetta, C., ... Cavallo, M. G. (2018). Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity. Nutrients, 10(4), [526]. https://doi.org/10.3390/nu10040526

CBE

Barchetta I, Cimini FA, Capoccia D, Bertoccini L, Ceccarelli V, Chiappetta C, Leonetti F, Di Cristofano C, Silecchia G, Orho-Melander M, Melander O, Cavallo MG. 2018. Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity. Nutrients. 10(4). https://doi.org/10.3390/nu10040526

MLA

Vancouver

Barchetta I, Cimini FA, Capoccia D, Bertoccini L, Ceccarelli V, Chiappetta C et al. Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity. Nutrients. 2018 Apr 23;10(4). 526. https://doi.org/10.3390/nu10040526

Author

Barchetta, Ilaria ; Cimini, Flavia Agata ; Capoccia, Danila ; Bertoccini, Laura ; Ceccarelli, Valentina ; Chiappetta, Caterina ; Leonetti, Frida ; Di Cristofano, Claudio ; Silecchia, Gianfranco ; Orho-Melander, Marju ; Melander, Olle ; Cavallo, Maria Gisella. / Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity. In: Nutrients. 2018 ; Vol. 10, No. 4.

RIS

TY - JOUR

T1 - Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity

AU - Barchetta, Ilaria

AU - Cimini, Flavia Agata

AU - Capoccia, Danila

AU - Bertoccini, Laura

AU - Ceccarelli, Valentina

AU - Chiappetta, Caterina

AU - Leonetti, Frida

AU - Di Cristofano, Claudio

AU - Silecchia, Gianfranco

AU - Orho-Melander, Marju

AU - Melander, Olle

AU - Cavallo, Maria Gisella

PY - 2018/4/23

Y1 - 2018/4/23

N2 - Neurotensin (NT) is a 13-amino acid peptide localized in the neuroendocrine cells of the small intestine, which promotes fat absorption and fatty acids translocation in response to lipid ingestion. NT-knock-out mice fed with a high-fat diet are protected from obesity, fatty liver, and the development of insulin-resistance. In humans, higher plasma levels of pro-NT, which is the stable circulating precursor of NT, predict obesity, type 2 diabetes (T2D), and cardiovascular disease. In obesity, the presence of visceral adipose tissue (VAT) inflammation leads to unfavorable metabolic outcomes and is associated with the development of T2D and non-alcoholic fatty liver disease (NAFLD). In this study, we investigated the relationship between plasma pro-NT levels and the presence of VAT inflammation in biopsies from 40 morbidly obese subjects undergoing bariatric surgery. We demonstrated that higher proNT levels are significantly associated with greater macrophages infiltration, HIF-1α, WISP-1, and UNC5B expression in VAT (all p < 0.01) due to the diagnosis of T2D and NAFLD. The overall results show that, in obesity, pro-NT is a biomarker of VAT inflammation and insulin-resistance. Additionally, NT may be involved in the development of dysmetabolic conditions likely mediated by increased gut fat absorption and the presence of a proinflammatory milieu in the adipose tissue.

AB - Neurotensin (NT) is a 13-amino acid peptide localized in the neuroendocrine cells of the small intestine, which promotes fat absorption and fatty acids translocation in response to lipid ingestion. NT-knock-out mice fed with a high-fat diet are protected from obesity, fatty liver, and the development of insulin-resistance. In humans, higher plasma levels of pro-NT, which is the stable circulating precursor of NT, predict obesity, type 2 diabetes (T2D), and cardiovascular disease. In obesity, the presence of visceral adipose tissue (VAT) inflammation leads to unfavorable metabolic outcomes and is associated with the development of T2D and non-alcoholic fatty liver disease (NAFLD). In this study, we investigated the relationship between plasma pro-NT levels and the presence of VAT inflammation in biopsies from 40 morbidly obese subjects undergoing bariatric surgery. We demonstrated that higher proNT levels are significantly associated with greater macrophages infiltration, HIF-1α, WISP-1, and UNC5B expression in VAT (all p < 0.01) due to the diagnosis of T2D and NAFLD. The overall results show that, in obesity, pro-NT is a biomarker of VAT inflammation and insulin-resistance. Additionally, NT may be involved in the development of dysmetabolic conditions likely mediated by increased gut fat absorption and the presence of a proinflammatory milieu in the adipose tissue.

KW - Adipose tissue inflammation

KW - Lipids

KW - Obesity

KW - Proneurotensin

UR - http://www.scopus.com/inward/record.url?scp=85046000026&partnerID=8YFLogxK

U2 - 10.3390/nu10040526

DO - 10.3390/nu10040526

M3 - Article

VL - 10

JO - Nutrients

T2 - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 4

M1 - 526

ER -