New approaches for brain repair-from rescue to reprogramming

Research output: Contribution to journalReview article

Abstract

The ability to repair or promote regeneration within the adult human brain has been envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors and cell transplants designed to rescue or replace a specific population of neurons, and the results have largely been disappointing. New approaches using stem-cell-derived cell products and direct cell reprogramming have opened up the possibility of reconstructing neural circuits and achieving better repair. In this Review we briefly summarize the history of neural repair and then discuss these new therapeutic approaches, especially with respect to chronic neurodegenerative disorders.

Details

Authors
Organisations
External organisations
  • University of Cambridge
  • Ludwig-Maximilian University of Munich
  • Munich Cluster for Systems Neurology
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Animals, Brain/cytology, Cellular Reprogramming/physiology, Fetal Tissue Transplantation, Humans, Nerve Regeneration/physiology, Neurodegenerative Diseases/pathology, Regenerative Medicine/methods, Stem Cell Transplantation
Original languageEnglish
Pages (from-to)329-334
JournalNature
Volume557
Issue number7705
Publication statusPublished - 2018 May
Publication categoryResearch
Peer-reviewedYes