New Kids on the Block: The Emerging Role of YAP/TAZ in Vascular Cell Mechanotransduction

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Abstract

YAP and TAZ are transcriptional coactivators controlled by the Hippo signaling pathway and by actin dynamics, and that are critical for cell growth and organ size control. YAP and TAZ are exquisitely sensitive to mechanical cues, such as substrate stiffness and shear stress, and the realization is growing that they play roles in arterial remodeling and aneurysm formation. This chapter discusses how YAP and TAZ are activated by mechanical cues, their potential arterial target genes, and plausible roles of YAP/TAZ in arterial health and disease. It is concluded that local and specific strategies are needed for YAP/TAZ targeting in cardiovascular disease treatment.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • Angiogenesis, Aortic aneurysm, Arterial remodeling, Atherosclerosis, Phenotypic modulation, Shear, WWTR1, YAP1
Original languageEnglish
Title of host publicationVascular Mechanobiology in Physiology and Disease
PublisherSpringer Science + Business Media
Pages69-96
Number of pages28
ISBN (Print)978-3-030-63164-2
Publication statusPublished - 2021
Publication categoryResearch
Peer-reviewedYes

Publication series

NameCardiac and Vascular Biology
Volume8
ISSN (Print)2509-7830
ISSN (Electronic)2509-7849