New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

Research output: Contribution to journalReview article

Abstract

Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.

Details

Authors
Organisations
External organisations
  • Regional Laboratories Region Skåne
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology
  • Cancer and Oncology
Original languageEnglish
Pages (from-to)1395-1401
JournalBlood
Volume130
Issue number12
Publication statusPublished - 2017 Sep 21
Publication categoryResearch
Peer-reviewedYes