New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia
Research output: Contribution to journal › Review article
Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Publication status||Published - 2017 Sep 21|