New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

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New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia. / Lilljebjörn, Henrik; Fioretos, Thoas.

In: Blood, Vol. 130, No. 12, 21.09.2017, p. 1395-1401.

Research output: Contribution to journalReview article

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Lilljebjörn, Henrik ; Fioretos, Thoas. / New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia. In: Blood. 2017 ; Vol. 130, No. 12. pp. 1395-1401.

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TY - JOUR

T1 - New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

AU - Lilljebjörn, Henrik

AU - Fioretos, Thoas

PY - 2017/9/21

Y1 - 2017/9/21

N2 - Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.

AB - Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.

UR - http://www.scopus.com/inward/record.url?scp=85029787852&partnerID=8YFLogxK

U2 - 10.1182/blood-2017-05-742643

DO - 10.1182/blood-2017-05-742643

M3 - Review article

VL - 130

SP - 1395

EP - 1401

JO - Blood

T2 - Blood

JF - Blood

SN - 1528-0020

IS - 12

ER -