New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

Research output: Contribution to journalArticle

Abstract

Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.

Details

Authors
  • Alexandra Fagerström
  • Mikael Nilsson
  • Ulf Berg
  • Roland Isaksson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)3067-3076
JournalOrganic and Biomolecular Chemistry
Volume4
Issue number16
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)