New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A
Research output: Contribution to journal › Article
Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Organic and Biomolecular Chemistry|
|Publication status||Published - 2006|
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)