NG2 cells, a new trail for Alzheimer's disease mechanisms?

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Abstract

Neuron Glial 2 (NG2) cells are glial cells known to serve as oligodendrocyte progenitors as well as modulators of the neuronal network. Altered NG2 cell morphology and up-regulation as well as increased shedding of the proteoglycan NG2 expressed on the cell surface have been described in rodent models of brain injury. Here we describe alterations in the human NG2 cell population in response to pathological changes characteristic of Alzheimer's disease (AD).

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  • Neurosciences
Original languageEnglish
Article number7
JournalActa neuropathologica communications
Volume1
Issue number1
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes

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