No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months

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Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.Results: Relevant baseline variables were similar in all groups. Changes over 6 months in duration of 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.ConclusionACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease.


  • Ronnie Willenheimer
  • Steen Juul-Möller
  • Lennart Forslund
  • Leif RW Erhardt
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)99-105
JournalCurrent Controlled Trials. Cardiovascular Medicine
Issue number2
Publication statusPublished - 2001
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cardiology (013242100), Emergency medicine/Medicine/Surgery (013240200), Cardiology Research Group (013242120)

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