No evidence for new dopaminergic neurons in the adult mammalian substantia nigra.

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No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. / Frielingsdorf, Helena; Schwarz, Katherine; Brundin, Patrik; Mohapel, Paul.

In: Proceedings of the National Academy of Sciences, Vol. 101, No. 27, 2004, p. 10177-10182.

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Frielingsdorf, Helena ; Schwarz, Katherine ; Brundin, Patrik ; Mohapel, Paul. / No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. In: Proceedings of the National Academy of Sciences. 2004 ; Vol. 101, No. 27. pp. 10177-10182.

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TY - JOUR

T1 - No evidence for new dopaminergic neurons in the adult mammalian substantia nigra.

AU - Frielingsdorf, Helena

AU - Schwarz, Katherine

AU - Brundin, Patrik

AU - Mohapel, Paul

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Wallenberg Neuroscience Centre, Lund (0131000110)

PY - 2004

Y1 - 2004

N2 - A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the substantia nigra. We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra.

AB - A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodological procedures to label dividing cells, we found no evidence of new dopaminergic neurons in the substantia nigra, either in normal or 6-hydroxydopamine-lesioned hemi-Parkinsonian rodents, or even after growth factor treatment. Furthermore, we found no evidence of neural stem cells emanating from the cerebroventricular system and migrating to the substantia nigra. We conclude that it is unlikely that dopaminergic neurons are generated in the adult mammalian substantia nigra.

U2 - 10.1073/pnas.0401229101

DO - 10.1073/pnas.0401229101

M3 - Article

VL - 101

SP - 10177

EP - 10182

JO - Proceedings of the National Academy of Sciences

T2 - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 1091-6490

IS - 27

ER -