No evidence of association of the PDCD1 gene with Type 1 diabetes

Research output: Contribution to journalArticle

Abstract

Aims To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM). This gene has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) as well as T1DM. Methods Genotyping of single nucleotide polymorphisms (SNPs) in the PDCD1 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), pyrosequencing and TaqMan in two separate cohorts of Swedish patients and control subjects: a family study consisting of 184 multiplex and eight simplex families and a case-control study consisting of 586 patients and 836 control subjects. Three SNPs were genotyped: PD-1 7146, PD-1 7785 and PD-1 8738. Results We did not detect any association or linkage between SNPs in PDCD1 and T1DM. We further performed a meta-analysis for association of PD-1 7146, PD-1 7785 and PD-1 8738 to T1DM. We detected heterogeneity in association with weak evidence for overall association. Conclusions We conclude that PDCD1 is unlikely to be a major susceptibility gene for T1DM.

Details

Authors
  • The Diabetes incidence in Sweden study group
External organisations
  • Karolinska Institutet
  • Skåne University Hospital
  • University of Washington
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • Type 1 diabetes, PDCD1, association, autoimmunity
Original languageEnglish
Pages (from-to)1473-1477
JournalDiabetic Medicine
Volume24
Issue number12
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes