No evidence of increased breast cancer risk for proven noncarriers from BRCA1 and BRCA2 families.

Research output: Contribution to journalArticle


In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish Civil Registration System. Prospective analysis showed no significantly increased risk for breast cancer in noncarriers with a hazard ratio of 0.67 [95 % confidence interval (CI) 0.32-1.42, p = 0.29] for all family members who tested negative and 0.87 (95 % CI 0.38-1.97, p = 0.73) for non-carries who were first-degree relatives of mutation carriers. Proven noncarriers from BRCA1 and BRCA2 families have no markedly increased risk for breast cancer compared to the general population, and our data do not suggest targeted breast cancer surveillance for noncarriers from BRCA1 and BRCA2 families.


  • Henriette Roed Nielsen
  • Janne Petersen
  • Lotte Krogh
  • Mef Nilbert
  • Anne-Bine Skytte
External organisations
  • Vejle Hospital
  • University of Copenhagen
  • Odense University Hospital
  • Copenhagen University Hospital
  • Aarhus University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)523–528
JournalFamilial Cancer
Issue number4
Early online date2016 Mar 7
Publication statusPublished - 2016 Oct
Publication categoryResearch