No interaction between H2 blockers and isoniazid

Research output: Contribution to journalArticle

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No interaction between H2 blockers and isoniazid. / Paulsen, Otto; Höglund, P; Nilsson, L G; Gredeby, H.

In: European Journal of Respiratory Diseases, Vol. 68, No. 4, 04.1986, p. 286-90.

Research output: Contribution to journalArticle

Harvard

Paulsen, O, Höglund, P, Nilsson, LG & Gredeby, H 1986, 'No interaction between H2 blockers and isoniazid', European Journal of Respiratory Diseases, vol. 68, no. 4, pp. 286-90.

APA

Paulsen, O., Höglund, P., Nilsson, L. G., & Gredeby, H. (1986). No interaction between H2 blockers and isoniazid. European Journal of Respiratory Diseases, 68(4), 286-90.

CBE

Paulsen O, Höglund P, Nilsson LG, Gredeby H. 1986. No interaction between H2 blockers and isoniazid. European Journal of Respiratory Diseases. 68(4):286-90.

MLA

Vancouver

Paulsen O, Höglund P, Nilsson LG, Gredeby H. No interaction between H2 blockers and isoniazid. European Journal of Respiratory Diseases. 1986 Apr;68(4):286-90.

Author

Paulsen, Otto ; Höglund, P ; Nilsson, L G ; Gredeby, H. / No interaction between H2 blockers and isoniazid. In: European Journal of Respiratory Diseases. 1986 ; Vol. 68, No. 4. pp. 286-90.

RIS

TY - JOUR

T1 - No interaction between H2 blockers and isoniazid

AU - Paulsen, Otto

AU - Höglund, P

AU - Nilsson, L G

AU - Gredeby, H

PY - 1986/4

Y1 - 1986/4

N2 - Antacids and anticholinergic drugs may delay gastric emptying and cause reduced absorption of isoniazid, but the influence of reduced gastric acidity has not been determined. In the present investigation, the influence of cimetidine and ranitidine on uptake and elimination of isoniazid was determined in six male and seven female healthy volunteers. The group comprised five rapid and eight slow acetylators, similar to the proportions in the general population. H2 blockers did not delay or reduce uptake of isoniazid, which thus seemed to be pH independent. Neither the acetylation of isoniazid nor the oxidative metabolism of acetylated isoniazid appeared to be affected by cimetidine or ranitidine.

AB - Antacids and anticholinergic drugs may delay gastric emptying and cause reduced absorption of isoniazid, but the influence of reduced gastric acidity has not been determined. In the present investigation, the influence of cimetidine and ranitidine on uptake and elimination of isoniazid was determined in six male and seven female healthy volunteers. The group comprised five rapid and eight slow acetylators, similar to the proportions in the general population. H2 blockers did not delay or reduce uptake of isoniazid, which thus seemed to be pH independent. Neither the acetylation of isoniazid nor the oxidative metabolism of acetylated isoniazid appeared to be affected by cimetidine or ranitidine.

KW - Absorption

KW - Acetylation

KW - Adult

KW - Chromatography, High Pressure Liquid

KW - Cimetidine

KW - Drug Interactions

KW - Female

KW - Half-Life

KW - Histamine H2 Antagonists

KW - Humans

KW - Isoniazid

KW - Kinetics

KW - Male

KW - Middle Aged

KW - Ranitidine

KW - Spectrophotometry

KW - Time Factors

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

VL - 68

SP - 286

EP - 290

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 1399-3003

IS - 4

ER -