No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

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title = "No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels",
abstract = "Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SNP x physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20{\%}) and the remainder as active (80{\%}). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (beta = 0.22 mmol/L [95{\%} CI 0.13-0.31], P = 1.63 X 10(-6)). All SNPs were associated with 2-h glucose (beta = 0.06-0.12 mmol/allele, P <= 1.53 X 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P >= 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. Diabetes 61:1291-1296, 2012",
author = "Scott, {Robert A.} and Chu, {Audrey Y.} and Niels Grarup and Manning, {Alisa K.} and Marie-France Hivert and Dmitry Shungin and Anke Toenjes and Ajay Yesupriya and Daniel Barnes and Nabila Bouatia-Naji and Glazer, {Nicole L.} and Jackson, {Anne U.} and Zoltan Kutalik and Vasiliki Lagou and Diana Marek and Rasmussen-Torvik, {Laura J.} and Stringham, {Heather M.} and Toshiko Tanaka and Mette Aadahl and Arking, {Dan E.} and Sven Bergmann and Eric Boerwinkle and Bonnycastle, {Lori L.} and Bornstein, {Stefan R.} and Eric Brunner and Bumpstead, {Suzannah J.} and Soren Brage and Carlson, {Olga D.} and Han Chen and Chen, {Yii-Der Ida} and Chines, {Peter S.} and Collins, {Francis S.} and Couper, {David J.} and Dennison, {Elaine M.} and Dowling, {Nicole F.} and Egan, {Josephine S.} and Ulf Ekelund and Erdos, {Michael R.} and Forouhi, {Nita G.} and Fox, {Caroline S.} and Goodarzi, {Mark O.} and Juergen Graessler and Stefan Gustafsson and Goeran Hallmans and Torben Hansen and Aroon Hingorani and Holloway, {John W.} and Hu, {Frank B.} and Bo Isomaa and Jameson, {Karen A.} and Ingegerd Johansson and Anna Jonsson and Torben Jorgensen and Mika Kivimaki and Peter Kovacs and Meena Kumari and Johanna Kuusisto and Markku Laakso and Cecile Lecoeur and Claire Levy-Marchal and Guo Li and Loos, {Ruth J. F.} and Valeriya Lyssenko and Michael Marmot and Pedro Marques-Vidal and Morken, {Mario A.} and Gabriele Mueller and North, {Kari E.} and Pankow, {James S.} and Felicity Payne and Inga Prokopenko and Psaty, {Bruce M.} and Frida Renstr{\"o}m and Ken Rice and Rotter, {Jerome I.} and Denis Rybin and Sandholt, {Camilla H.} and Sayer, {Avan A.} and Peter Shrader and Schwarz, {Peter E. H.} and Siscovick, {David S.} and Alena Stancakova and Michael Stumvoll and Teslovich, {Tanya M.} and Gerard Waeber and Williams, {Gordon H.} and Witte, {Daniel R.} and Wood, {Andrew R.} and Weijia Xie and Michael Boehnke and Cyrus Cooper and Luigi Ferrucci and Philippe Froguel and Leif Groop and Kao, {W. H. Linda} and Peter Vollenweider and Mark Walker and Watanabe, {Richard M.} and Oluf Pedersen and Meigs, {James B.} and Erik Ingelsson and Ines Barroso and Florez, {Jose C.} and Paul Franks and Josee Dupuis and Wareham, {Nicholas J.} and Claudia Langenberg",
year = "2012",
doi = "10.2337/db11-0973",
language = "English",
volume = "61",
pages = "1291--1296",
journal = "Diabetes",
issn = "1939-327X",
publisher = "American Diabetes Association Inc.",
number = "5",