No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Research output: Contribution to journalArticle

Standard

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels. / Scott, Robert A.; Chu, Audrey Y.; Grarup, Niels; Manning, Alisa K.; Hivert, Marie-France; Shungin, Dmitry; Toenjes, Anke; Yesupriya, Ajay; Barnes, Daniel; Bouatia-Naji, Nabila; Glazer, Nicole L.; Jackson, Anne U.; Kutalik, Zoltan; Lagou, Vasiliki; Marek, Diana; Rasmussen-Torvik, Laura J.; Stringham, Heather M.; Tanaka, Toshiko; Aadahl, Mette; Arking, Dan E.; Bergmann, Sven; Boerwinkle, Eric; Bonnycastle, Lori L.; Bornstein, Stefan R.; Brunner, Eric; Bumpstead, Suzannah J.; Brage, Soren; Carlson, Olga D.; Chen, Han; Chen, Yii-Der Ida; Chines, Peter S.; Collins, Francis S.; Couper, David J.; Dennison, Elaine M.; Dowling, Nicole F.; Egan, Josephine S.; Ekelund, Ulf; Erdos, Michael R.; Forouhi, Nita G.; Fox, Caroline S.; Goodarzi, Mark O.; Graessler, Juergen; Gustafsson, Stefan; Hallmans, Goeran; Hansen, Torben; Hingorani, Aroon; Holloway, John W.; Hu, Frank B.; Isomaa, Bo; Jameson, Karen A.; Johansson, Ingegerd; Jonsson, Anna; Jorgensen, Torben; Kivimaki, Mika; Kovacs, Peter; Kumari, Meena; Kuusisto, Johanna; Laakso, Markku; Lecoeur, Cecile; Levy-Marchal, Claire; Li, Guo; Loos, Ruth J. F.; Lyssenko, Valeriya; Marmot, Michael; Marques-Vidal, Pedro; Morken, Mario A.; Mueller, Gabriele; North, Kari E.; Pankow, James S.; Payne, Felicity; Prokopenko, Inga; Psaty, Bruce M.; Renström, Frida; Rice, Ken; Rotter, Jerome I.; Rybin, Denis; Sandholt, Camilla H.; Sayer, Avan A.; Shrader, Peter; Schwarz, Peter E. H.; Siscovick, David S.; Stancakova, Alena; Stumvoll, Michael; Teslovich, Tanya M.; Waeber, Gerard; Williams, Gordon H.; Witte, Daniel R.; Wood, Andrew R.; Xie, Weijia; Boehnke, Michael; Cooper, Cyrus; Ferrucci, Luigi; Froguel, Philippe; Groop, Leif; Kao, W. H. Linda; Vollenweider, Peter; Walker, Mark; Watanabe, Richard M.; Pedersen, Oluf; Meigs, James B.; Ingelsson, Erik; Barroso, Ines; Florez, Jose C.; Franks, Paul; Dupuis, Josee; Wareham, Nicholas J.; Langenberg, Claudia.

In: Diabetes, Vol. 61, No. 5, 2012, p. 1291-1296.

Research output: Contribution to journalArticle

Harvard

Scott, RA, Chu, AY, Grarup, N, Manning, AK, Hivert, M-F, Shungin, D, Toenjes, A, Yesupriya, A, Barnes, D, Bouatia-Naji, N, Glazer, NL, Jackson, AU, Kutalik, Z, Lagou, V, Marek, D, Rasmussen-Torvik, LJ, Stringham, HM, Tanaka, T, Aadahl, M, Arking, DE, Bergmann, S, Boerwinkle, E, Bonnycastle, LL, Bornstein, SR, Brunner, E, Bumpstead, SJ, Brage, S, Carlson, OD, Chen, H, Chen, Y-DI, Chines, PS, Collins, FS, Couper, DJ, Dennison, EM, Dowling, NF, Egan, JS, Ekelund, U, Erdos, MR, Forouhi, NG, Fox, CS, Goodarzi, MO, Graessler, J, Gustafsson, S, Hallmans, G, Hansen, T, Hingorani, A, Holloway, JW, Hu, FB, Isomaa, B, Jameson, KA, Johansson, I, Jonsson, A, Jorgensen, T, Kivimaki, M, Kovacs, P, Kumari, M, Kuusisto, J, Laakso, M, Lecoeur, C, Levy-Marchal, C, Li, G, Loos, RJF, Lyssenko, V, Marmot, M, Marques-Vidal, P, Morken, MA, Mueller, G, North, KE, Pankow, JS, Payne, F, Prokopenko, I, Psaty, BM, Renström, F, Rice, K, Rotter, JI, Rybin, D, Sandholt, CH, Sayer, AA, Shrader, P, Schwarz, PEH, Siscovick, DS, Stancakova, A, Stumvoll, M, Teslovich, TM, Waeber, G, Williams, GH, Witte, DR, Wood, AR, Xie, W, Boehnke, M, Cooper, C, Ferrucci, L, Froguel, P, Groop, L, Kao, WHL, Vollenweider, P, Walker, M, Watanabe, RM, Pedersen, O, Meigs, JB, Ingelsson, E, Barroso, I, Florez, JC, Franks, P, Dupuis, J, Wareham, NJ & Langenberg, C 2012, 'No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels', Diabetes, vol. 61, no. 5, pp. 1291-1296. https://doi.org/10.2337/db11-0973

APA

Scott, R. A., Chu, A. Y., Grarup, N., Manning, A. K., Hivert, M-F., Shungin, D., ... Langenberg, C. (2012). No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels. Diabetes, 61(5), 1291-1296. https://doi.org/10.2337/db11-0973

CBE

Scott RA, Chu AY, Grarup N, Manning AK, Hivert M-F, Shungin D, Toenjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadahl M, Arking DE, Bergmann S, Boerwinkle E, Bonnycastle LL, Bornstein SR, Brunner E, Bumpstead SJ, Brage S, Carlson OD, Chen H, Chen Y-DI, Chines PS, Collins FS, Couper DJ, Dennison EM, Dowling NF, Egan JS, Ekelund U, Erdos MR, Forouhi NG, Fox CS, Goodarzi MO, Graessler J, Gustafsson S, Hallmans G, Hansen T, Hingorani A, Holloway JW, Hu FB, Isomaa B, Jameson KA, Johansson I, Jonsson A, Jorgensen T, Kivimaki M, Kovacs P, Kumari M, Kuusisto J, Laakso M, Lecoeur C, Levy-Marchal C, Li G, Loos RJF, Lyssenko V, Marmot M, Marques-Vidal P, Morken MA, Mueller G, North KE, Pankow JS, Payne F, Prokopenko I, Psaty BM, Renström F, Rice K, Rotter JI, Rybin D, Sandholt CH, Sayer AA, Shrader P, Schwarz PEH, Siscovick DS, Stancakova A, Stumvoll M, Teslovich TM, Waeber G, Williams GH, Witte DR, Wood AR, Xie W, Boehnke M, Cooper C, Ferrucci L, Froguel P, Groop L, Kao WHL, Vollenweider P, Walker M, Watanabe RM, Pedersen O, Meigs JB, Ingelsson E, Barroso I, Florez JC, Franks P, Dupuis J, Wareham NJ, Langenberg C. 2012. No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels. Diabetes. 61(5):1291-1296. https://doi.org/10.2337/db11-0973

MLA

Vancouver

Author

Scott, Robert A. ; Chu, Audrey Y. ; Grarup, Niels ; Manning, Alisa K. ; Hivert, Marie-France ; Shungin, Dmitry ; Toenjes, Anke ; Yesupriya, Ajay ; Barnes, Daniel ; Bouatia-Naji, Nabila ; Glazer, Nicole L. ; Jackson, Anne U. ; Kutalik, Zoltan ; Lagou, Vasiliki ; Marek, Diana ; Rasmussen-Torvik, Laura J. ; Stringham, Heather M. ; Tanaka, Toshiko ; Aadahl, Mette ; Arking, Dan E. ; Bergmann, Sven ; Boerwinkle, Eric ; Bonnycastle, Lori L. ; Bornstein, Stefan R. ; Brunner, Eric ; Bumpstead, Suzannah J. ; Brage, Soren ; Carlson, Olga D. ; Chen, Han ; Chen, Yii-Der Ida ; Chines, Peter S. ; Collins, Francis S. ; Couper, David J. ; Dennison, Elaine M. ; Dowling, Nicole F. ; Egan, Josephine S. ; Ekelund, Ulf ; Erdos, Michael R. ; Forouhi, Nita G. ; Fox, Caroline S. ; Goodarzi, Mark O. ; Graessler, Juergen ; Gustafsson, Stefan ; Hallmans, Goeran ; Hansen, Torben ; Hingorani, Aroon ; Holloway, John W. ; Hu, Frank B. ; Isomaa, Bo ; Jameson, Karen A. ; Johansson, Ingegerd ; Jonsson, Anna ; Jorgensen, Torben ; Kivimaki, Mika ; Kovacs, Peter ; Kumari, Meena ; Kuusisto, Johanna ; Laakso, Markku ; Lecoeur, Cecile ; Levy-Marchal, Claire ; Li, Guo ; Loos, Ruth J. F. ; Lyssenko, Valeriya ; Marmot, Michael ; Marques-Vidal, Pedro ; Morken, Mario A. ; Mueller, Gabriele ; North, Kari E. ; Pankow, James S. ; Payne, Felicity ; Prokopenko, Inga ; Psaty, Bruce M. ; Renström, Frida ; Rice, Ken ; Rotter, Jerome I. ; Rybin, Denis ; Sandholt, Camilla H. ; Sayer, Avan A. ; Shrader, Peter ; Schwarz, Peter E. H. ; Siscovick, David S. ; Stancakova, Alena ; Stumvoll, Michael ; Teslovich, Tanya M. ; Waeber, Gerard ; Williams, Gordon H. ; Witte, Daniel R. ; Wood, Andrew R. ; Xie, Weijia ; Boehnke, Michael ; Cooper, Cyrus ; Ferrucci, Luigi ; Froguel, Philippe ; Groop, Leif ; Kao, W. H. Linda ; Vollenweider, Peter ; Walker, Mark ; Watanabe, Richard M. ; Pedersen, Oluf ; Meigs, James B. ; Ingelsson, Erik ; Barroso, Ines ; Florez, Jose C. ; Franks, Paul ; Dupuis, Josee ; Wareham, Nicholas J. ; Langenberg, Claudia. / No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels. In: Diabetes. 2012 ; Vol. 61, No. 5. pp. 1291-1296.

RIS

TY - JOUR

T1 - No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

AU - Scott, Robert A.

AU - Chu, Audrey Y.

AU - Grarup, Niels

AU - Manning, Alisa K.

AU - Hivert, Marie-France

AU - Shungin, Dmitry

AU - Toenjes, Anke

AU - Yesupriya, Ajay

AU - Barnes, Daniel

AU - Bouatia-Naji, Nabila

AU - Glazer, Nicole L.

AU - Jackson, Anne U.

AU - Kutalik, Zoltan

AU - Lagou, Vasiliki

AU - Marek, Diana

AU - Rasmussen-Torvik, Laura J.

AU - Stringham, Heather M.

AU - Tanaka, Toshiko

AU - Aadahl, Mette

AU - Arking, Dan E.

AU - Bergmann, Sven

AU - Boerwinkle, Eric

AU - Bonnycastle, Lori L.

AU - Bornstein, Stefan R.

AU - Brunner, Eric

AU - Bumpstead, Suzannah J.

AU - Brage, Soren

AU - Carlson, Olga D.

AU - Chen, Han

AU - Chen, Yii-Der Ida

AU - Chines, Peter S.

AU - Collins, Francis S.

AU - Couper, David J.

AU - Dennison, Elaine M.

AU - Dowling, Nicole F.

AU - Egan, Josephine S.

AU - Ekelund, Ulf

AU - Erdos, Michael R.

AU - Forouhi, Nita G.

AU - Fox, Caroline S.

AU - Goodarzi, Mark O.

AU - Graessler, Juergen

AU - Gustafsson, Stefan

AU - Hallmans, Goeran

AU - Hansen, Torben

AU - Hingorani, Aroon

AU - Holloway, John W.

AU - Hu, Frank B.

AU - Isomaa, Bo

AU - Jameson, Karen A.

AU - Johansson, Ingegerd

AU - Jonsson, Anna

AU - Jorgensen, Torben

AU - Kivimaki, Mika

AU - Kovacs, Peter

AU - Kumari, Meena

AU - Kuusisto, Johanna

AU - Laakso, Markku

AU - Lecoeur, Cecile

AU - Levy-Marchal, Claire

AU - Li, Guo

AU - Loos, Ruth J. F.

AU - Lyssenko, Valeriya

AU - Marmot, Michael

AU - Marques-Vidal, Pedro

AU - Morken, Mario A.

AU - Mueller, Gabriele

AU - North, Kari E.

AU - Pankow, James S.

AU - Payne, Felicity

AU - Prokopenko, Inga

AU - Psaty, Bruce M.

AU - Renström, Frida

AU - Rice, Ken

AU - Rotter, Jerome I.

AU - Rybin, Denis

AU - Sandholt, Camilla H.

AU - Sayer, Avan A.

AU - Shrader, Peter

AU - Schwarz, Peter E. H.

AU - Siscovick, David S.

AU - Stancakova, Alena

AU - Stumvoll, Michael

AU - Teslovich, Tanya M.

AU - Waeber, Gerard

AU - Williams, Gordon H.

AU - Witte, Daniel R.

AU - Wood, Andrew R.

AU - Xie, Weijia

AU - Boehnke, Michael

AU - Cooper, Cyrus

AU - Ferrucci, Luigi

AU - Froguel, Philippe

AU - Groop, Leif

AU - Kao, W. H. Linda

AU - Vollenweider, Peter

AU - Walker, Mark

AU - Watanabe, Richard M.

AU - Pedersen, Oluf

AU - Meigs, James B.

AU - Ingelsson, Erik

AU - Barroso, Ines

AU - Florez, Jose C.

AU - Franks, Paul

AU - Dupuis, Josee

AU - Wareham, Nicholas J.

AU - Langenberg, Claudia

PY - 2012

Y1 - 2012

N2 - Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SNP x physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (beta = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 X 10(-6)). All SNPs were associated with 2-h glucose (beta = 0.06-0.12 mmol/allele, P <= 1.53 X 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P >= 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. Diabetes 61:1291-1296, 2012

AB - Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) X BMI and SNP x physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (beta = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 X 10(-6)). All SNPs were associated with 2-h glucose (beta = 0.06-0.12 mmol/allele, P <= 1.53 X 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P >= 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions. Diabetes 61:1291-1296, 2012

U2 - 10.2337/db11-0973

DO - 10.2337/db11-0973

M3 - Article

VL - 61

SP - 1291

EP - 1296

JO - Diabetes

JF - Diabetes

SN - 1939-327X

IS - 5

ER -