Non-fibrosing sclerosing epithelioid fibrosarcoma: An unusual variant.

Research output: Contribution to journalLetter

Abstract

Sclerosing epithelioid fibrosarcoma (SEF), first described in 1995, is a rare aggressive sarcoma morphologically defined by "epithelioid fibroblasts arranged in distinct cords and nests in a densely sclerotic, hyalinised stroma". SEF can mimic metastatic carcinoma within desmoplastic stroma, lymphoma and other mesenchymal neoplasms such as myoepithelioma, making it difficult to diagnose. In a subset of cases there is morphological overlap between SEF and low grade fibromyxoid sarcoma (LGFMS), a low grade fibroblastic sarcoma. Progression of LGFMS to SEF in single cases is well documented. Recent studies detected EWSR1-CREB3L1 fusion transcripts in a high proportion of SEF. This article is protected by copyright. All rights reserved.

Details

Authors
  • Florian Puls
  • Linda Magnusson
  • Angela Niblett
  • Hassan Douis
  • David Peake
  • Philippe Taniere
  • Lars-Gunnar Kindblom
  • Fredrik Mertens
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
JournalHistopathology
Early online date2015 Jul 25
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedNo