Non-immune hydrops fetalis was rare in Sweden during 1997-2015, but cases were associated with complications and poor prognosis

Research output: Contribution to journalArticle

Bibtex

@article{9583a29335cc495c86fea52a61fd8478,
title = "Non-immune hydrops fetalis was rare in Sweden during 1997-2015, but cases were associated with complications and poor prognosis",
abstract = "Aim: The study was designed to document the incidence of non-immune hydrops fetalis (NIHF) at birth and characterise associated outcomes and obstetric complications. Methods: Data on more than 1.9 million births were extracted from the Swedish Birth Register for 1997-2015. Pregnancies not affected by NIHF served as controls. National registers on mortality and hospitalisations provided follow-up information. Results: There were 309 cases of NIHF at birth corresponding to an incidence of 1.6 per 10 000, lower than in previous studies. NIHF was more frequent in mothers aged ≥35 years and with a history of stillbirth. Preterm delivery occurred in 77.7% in the NIHF group, including 31.7% before 32 weeks of gestation. Multiple births and Caesarean sections were reported more frequent in the NIHF group. NIHF was associated with poor outcome with 14.6% stillbirths and in 26.5% early neonatal death. Overall, 58.7% of live-born children with NIHF were alive at 12 months compared with 99.7% of controls. The most common causes of death were cardiovascular diseases and thoracic abnormalities. Conclusion: NIHF at birth is associated with obstetric complications and poor prognosis for the neonate related to underlying disease. The low incidence of NIHF observed in this study may reflect well-developed antenatal care.",
keywords = "incidence, non-immune hydrops fetalis, obstetric complications, poor prognosis, population study",
author = "Catharina Whybra and Karin K{\"a}ll{\'e}n and Hansson, {Stefan R.} and Rolf Gunnarsson",
year = "2020",
doi = "10.1111/apa.15260",
language = "English",
volume = "109",
pages = "2570--2577",
journal = "Acta P{\ae}diatrica",
issn = "1651-2227",
publisher = "Wiley-Blackwell",
number = "12",

}