Noninvasive techniques for prevention of intradialytic hypotension

Research output: Contribution to journalArticle


Episodes of hypotension during hemodialysis treatment constitutes an important clinical problem which has received considerable attention in recent years. Despite the fact that numerous approaches to reducing the frequency of intradialytic hypotension (IDH) have been proposed and evaluated, the problem has not yet found a definitive solution--an observation which, in particular, applies to episodes of acute, symptomatic hypotension. This overview covers recent advances in methodology for predicting and preventing IDH. Following a brief overview of well-established hypotension-related variables, including blood pressure, blood temperature, relative blood volume, and bioimpedance, special attention is given to electrocardiographic and photoplethysmographic (PPG) variables and their significance for IDH prediction. It is concluded that cardiovascular variables which reflect heart rate variability, heart rate turbulence, and baroreflex sensitivity are important to explore in feedback control hemodialysis systems so as to improve their performance. The analysis of hemodialysis-related changes in PPG pulse wave properties hold considerable promise for improving prediction.


External organisations
  • University of Zaragoza
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Biotechnology


  • Electrocardiography, Feedback, Hemodynamics, Humans, Hypotension, Models, Statistical, Monitoring, Physiologic, Photoplethysmography, Signal Processing, Computer-Assisted, Vital Signs, Journal Article, Research Support, Non-U.S. Gov't, Review
Original languageEnglish
Pages (from-to)45-59
Number of pages15
JournalIEEE Transactions on Biomedical Engineering
Publication statusPublished - 2012
Publication categoryResearch