Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus

Research output: Contribution to journalArticle

Abstract

Neonatal insulin-dependent diabetes mellitus (IDDM) occurs rarely. A sibship of two HLA-Dw314-positive boys who developed IDDM within the 1st wk of life is described. Although the HLA-D region genotype would be consistent with IDDM associated with islet autoimmunity, islet cell antibodies were negative, but both boys exhibited the presence of a novel autoantibody that reacted specifically with a conspicuous, yet unidentified, determinant in the interstitial tissue among the acinar cells. The possible relationship between this acinar nonislet autoantibody and permanent neonatal diabetes remains to be established.

Details

Authors
External organisations
  • Skåne University Hospital
  • Hagedorn Research Institute
Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalDiabetes
Volume37
Issue number3
Publication statusPublished - 1988 Jan 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes