Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus

Research output: Contribution to journalArticle


Neonatal insulin-dependent diabetes mellitus (IDDM) occurs rarely. A sibship of two HLA-Dw314-positive boys who developed IDDM within the 1st wk of life is described. Although the HLA-D region genotype would be consistent with IDDM associated with islet autoimmunity, islet cell antibodies were negative, but both boys exhibited the presence of a novel autoantibody that reacted specifically with a conspicuous, yet unidentified, determinant in the interstitial tissue among the acinar cells. The possible relationship between this acinar nonislet autoantibody and permanent neonatal diabetes remains to be established.


External organisations
  • Skåne University Hospital
  • Hagedorn Research Institute
Original languageEnglish
Pages (from-to)347-350
Number of pages4
Issue number3
Publication statusPublished - 1988 Jan 1
Publication categoryResearch
Externally publishedYes