Non-traditional roles of complement in type 2 diabetes: Metabolism, insulin secretion and homeostasis

Research output: Contribution to journalArticle

Abstract

Type 2 Diabetes (T2D) is a disease of increasing importance and represents a growing burden on global healthcare and human health. In T2D, loss of effectiveness of insulin signaling in peripheral tissues cannot be compensated for by adequate insulin secretion, leading to hyperglycemia and resultant complications. In recent years, inflammation has been identified as a central component of T2D, both in inducing peripheral insulin resistance as well as in the pancreatic islet, where it contributes to loss of insulin secretion and death of insulin-secreting beta cells. In this review we will focus on non-traditional roles of complement proteins which have been identified in T2D-associated inflammation, beta cell secretory function, and in maintaining homeostasis of the pancreatic islet. Improved understanding of both traditional and novel roles of complement proteins in T2D may lead to new therapeutic approaches for this global disease.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area
  • Endocrinology and Diabetes

Keywords

  • C4BP, CD59, Complement, Diabetes, Inflammasome, Insulin secretion
Original languageEnglish
Pages (from-to)34-42
Number of pages9
JournalMolecular Immunology
Volume84
Early online date2016 Jul 15
Publication statusPublished - 2017 Apr
Publication categoryResearch
Peer-reviewedYes