Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC plus autologous stem-cell support: still very long survival but late relapses do occur

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@article{e3739336eb244fa88d10d3711aa82a55,
title = "Nordic MCL2 trial update: six-year follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC plus autologous stem-cell support: still very long survival but late relapses do occur",
abstract = "Mantle cell lymphoma (MCL) is a heterogenic non-Hodgkin lymphoma entity, with a median survival of about 5 years. In 2008 we reported the early based on the median observation time of 4 years results of the Nordic Lymphoma Group MCL2 study of frontline intensive induction immunochemotherapy and autologous stem cell transplantation (ASCT), with more than 60{\%} event-free survival at 5 years, and no subsequent relapses reported. Here we present an update after a median observation time of 6.5 years. The overall results are still excellent, with median overall survival and response duration longer than 10 years, and a median event-free survival of 7.4 years. However, six patients have now progressed later than 5 years after end of treatment. The international MCL Prognostic Index (MIPI) and Ki-67-expression were the only independent prognostic factors. Subdivided by the MIPI-Biological Index (MIPI + Ki-67, MIPI-B), more than 70{\%} of patients with low-intermediate MIPI-B were alive at 10 years, but only 23{\%} of the patients with high MIPI-B. These results, although highly encouraging regarding the majority of the patients, underline the need of a risk-adapted treatment strategy for MCL. The study was registered at as ISRCTN 87866680.",
keywords = "mantle cell lymphoma, autologous stem cell transplant, high-dose AraC, rituximab, pre-emptive therapy",
author = "Geisler, {Christian H.} and Arne Kolstad and Anna Laurell and Mats Jerkeman and Riikka Raty and Andersen, {Niels S.} and Pedersen, {Lone B.} and Mikael Eriksson and Marie Nordstrom and Eva Kimby and Hans Bentzen and Outi Kuittinen and Lauritzsen, {Grete F.} and Herman Nilsson-Ehle and Elisabeth Ralfkiaer and Mats Ehinger and Christer Sundstrom and Jan Delabie and Marja-Liisa Karjalainen-Lindsberg and Peter Brown and Erkki Elonen",
year = "2012",
doi = "10.1111/j.1365-2141.2012.09174.x",
language = "English",
volume = "158",
pages = "355--362",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Federation of European Neuroscience Societies and Blackwell Publishing Ltd",
number = "3",

}