North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

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North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. / Eussen, Simone J. P. M.; Nilsen, Roy M.; Midttun, Oivind; Hustad, Steinar; IJssennagger, Noortje; Meyer, Klaus; Fredriksen, Ase; Ulvik, Arve; Ueland, Per M.; Brennan, Paul; Johansson, Mattias; Bueno-de-Mesquita, Bas; Vineis, Paolo; Chuang, Shu-Chun; Boutron-Ruault, Marie Christine; Dossus, Laure; Perquier, Florence; Overvad, Kim; Teucher, Birgit; Grote, Verena A.; Trichopoulou, Antonia; Adarakis, George; Plada, Maria; Sieri, Sabina; Tumino, Rosario; Santucci de Magistris, Maria; Ros, Martine M.; Peeters, Petra H. M.; Luisa Redondo, Maria; Zamora-Ros, Raul; Chirlaque, Maria-Dolores; Ardanaz, Eva; Sonestedt, Emily; Ericson, Ulrika; Schneede, Joern; van Guelpen, Bethany; Wark, Petra A.; Gallo, Valentina; Norat, Teresa; Riboli, Elio; Vollset, Stein Emil.

In: British Journal of Nutrition, Vol. 110, No. 2, 2013, p. 363-374.

Research output: Contribution to journalArticle

Harvard

Eussen, SJPM, Nilsen, RM, Midttun, O, Hustad, S, IJssennagger, N, Meyer, K, Fredriksen, A, Ulvik, A, Ueland, PM, Brennan, P, Johansson, M, Bueno-de-Mesquita, B, Vineis, P, Chuang, S-C, Boutron-Ruault, MC, Dossus, L, Perquier, F, Overvad, K, Teucher, B, Grote, VA, Trichopoulou, A, Adarakis, G, Plada, M, Sieri, S, Tumino, R, Santucci de Magistris, M, Ros, MM, Peeters, PHM, Luisa Redondo, M, Zamora-Ros, R, Chirlaque, M-D, Ardanaz, E, Sonestedt, E, Ericson, U, Schneede, J, van Guelpen, B, Wark, PA, Gallo, V, Norat, T, Riboli, E & Vollset, SE 2013, 'North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study', British Journal of Nutrition, vol. 110, no. 2, pp. 363-374. https://doi.org/10.1017/S0007114512004990

APA

CBE

Eussen SJPM, Nilsen RM, Midttun O, Hustad S, IJssennagger N, Meyer K, Fredriksen A, Ulvik A, Ueland PM, Brennan P, Johansson M, Bueno-de-Mesquita B, Vineis P, Chuang S-C, Boutron-Ruault MC, Dossus L, Perquier F, Overvad K, Teucher B, Grote VA, Trichopoulou A, Adarakis G, Plada M, Sieri S, Tumino R, Santucci de Magistris M, Ros MM, Peeters PHM, Luisa Redondo M, Zamora-Ros R, Chirlaque M-D, Ardanaz E, Sonestedt E, Ericson U, Schneede J, van Guelpen B, Wark PA, Gallo V, Norat T, Riboli E, Vollset SE. 2013. North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. British Journal of Nutrition. 110(2):363-374. https://doi.org/10.1017/S0007114512004990

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Author

Eussen, Simone J. P. M. ; Nilsen, Roy M. ; Midttun, Oivind ; Hustad, Steinar ; IJssennagger, Noortje ; Meyer, Klaus ; Fredriksen, Ase ; Ulvik, Arve ; Ueland, Per M. ; Brennan, Paul ; Johansson, Mattias ; Bueno-de-Mesquita, Bas ; Vineis, Paolo ; Chuang, Shu-Chun ; Boutron-Ruault, Marie Christine ; Dossus, Laure ; Perquier, Florence ; Overvad, Kim ; Teucher, Birgit ; Grote, Verena A. ; Trichopoulou, Antonia ; Adarakis, George ; Plada, Maria ; Sieri, Sabina ; Tumino, Rosario ; Santucci de Magistris, Maria ; Ros, Martine M. ; Peeters, Petra H. M. ; Luisa Redondo, Maria ; Zamora-Ros, Raul ; Chirlaque, Maria-Dolores ; Ardanaz, Eva ; Sonestedt, Emily ; Ericson, Ulrika ; Schneede, Joern ; van Guelpen, Bethany ; Wark, Petra A. ; Gallo, Valentina ; Norat, Teresa ; Riboli, Elio ; Vollset, Stein Emil. / North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. In: British Journal of Nutrition. 2013 ; Vol. 110, No. 2. pp. 363-374.

RIS

TY - JOUR

T1 - North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

AU - Eussen, Simone J. P. M.

AU - Nilsen, Roy M.

AU - Midttun, Oivind

AU - Hustad, Steinar

AU - IJssennagger, Noortje

AU - Meyer, Klaus

AU - Fredriksen, Ase

AU - Ulvik, Arve

AU - Ueland, Per M.

AU - Brennan, Paul

AU - Johansson, Mattias

AU - Bueno-de-Mesquita, Bas

AU - Vineis, Paolo

AU - Chuang, Shu-Chun

AU - Boutron-Ruault, Marie Christine

AU - Dossus, Laure

AU - Perquier, Florence

AU - Overvad, Kim

AU - Teucher, Birgit

AU - Grote, Verena A.

AU - Trichopoulou, Antonia

AU - Adarakis, George

AU - Plada, Maria

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Santucci de Magistris, Maria

AU - Ros, Martine M.

AU - Peeters, Petra H. M.

AU - Luisa Redondo, Maria

AU - Zamora-Ros, Raul

AU - Chirlaque, Maria-Dolores

AU - Ardanaz, Eva

AU - Sonestedt, Emily

AU - Ericson, Ulrika

AU - Schneede, Joern

AU - van Guelpen, Bethany

AU - Wark, Petra A.

AU - Gallo, Valentina

AU - Norat, Teresa

AU - Riboli, Elio

AU - Vollset, Stein Emil

PY - 2013

Y1 - 2013

N2 - Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10.4 nmol/l; women, 10.7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north-south gradient. Vitamin B-2 concentrations were highest in Northern Europe (men, 22.2 nmol/l; women, 26.0 nmol/l) and decreased towards Southern Europe (P-trend < 0.001). Vitamin B-6 concentrations were highest in Central Europe in men (77.3 nmol/l) and highest in the North among women (70.4 nmol/l), with decreasing concentrations towards Southern Europe in women (P-trend < 0.001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle.

AB - Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10.4 nmol/l; women, 10.7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north-south gradient. Vitamin B-2 concentrations were highest in Northern Europe (men, 22.2 nmol/l; women, 26.0 nmol/l) and decreased towards Southern Europe (P-trend < 0.001). Vitamin B-6 concentrations were highest in Central Europe in men (77.3 nmol/l) and highest in the North among women (70.4 nmol/l), with decreasing concentrations towards Southern Europe in women (P-trend < 0.001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle.

KW - B-vitamins

KW - Amino acids

KW - One-carbon metabolism

KW - Europe

U2 - 10.1017/S0007114512004990

DO - 10.1017/S0007114512004990

M3 - Article

VL - 110

SP - 363

EP - 374

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 1475-2662

IS - 2

ER -