Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.

Research output: Contribution to journalArticle


title = "Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.",
abstract = "An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5{\%}) used the IGHV3-21 gene with 254/437 (58{\%}) classified as subset #2. Within subset #2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non-subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P = .002). Subset #2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non-subset #2/IGHV3-21 (22 vs 60 months, P = .001). No such difference was observed between non-subset #2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status. In conclusion, IGHV3-21 CLL should not be axiomatically considered a homogeneous entity with adverse prognosis, given that only subset #2 emerges as uniformly aggressive, contrasting non-subset #2/IGVH3-21 patients whose prognosis depends on IGHV mutational status as the remaining CLL.",
author = "Panagiotis Baliakas and Andreas Agathangelidis and Anastasia Hadzidimitriou and Lesley-Ann Sutton and Eva Minga and Athina Tsanousa and Lydia Scarf{\`o} and Zadie Davis and Xiao-Jie Yan and Tait Shanafelt and Karla Plevova and Yorick Sandberg and Vojdeman, {Fie Juhl} and Myriam Boudjogra and Tatiana Tzenou and Maria Chatzouli and Chu, {Charles C} and Silvio Veronese and Anne Gardiner and Larry Mansouri and Smedby, {Karin E} and Pedersen, {Lone Bredo} and Denis Moreno and {Van Lom}, Kirsten and V{\'e}ronique Giudicelli and Francova, {Hana Skuhrova} and Florence Nguyen-Khac and Panagiotis Panagiotidis and Gunnar Juliusson and Lefteris Angelis and Achilles Anagnostopoulos and Marie-Paule Lefranc and Monica Facco and Livio Trentin and Mark Catherwood and Marco Montillo and Geisler, {Christian H} and Langerak, {Anton W} and Sarka Pospisilova and Nicholas Chiorazzi and David Oscier and Jelinek, {Diane F} and Nikos Darzentas and Chrysoula Belessi and Frederic Davi and Paolo Ghia and Richard Rosenquist and Kostas Stamatopoulos",
year = "2015",
doi = "10.1182/blood-2014-09-600874",
language = "English",
volume = "125",
pages = "856--859",
journal = "Blood",
issn = "1528-0020",
publisher = "American Society of Hematology",
number = "5",