No-touch saphenous vein grafts in coronary artery surgery (SWEDEGRAFT): Rationale and design of a multicenter, prospective, registry-based randomized clinical trial

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No-touch saphenous vein grafts in coronary artery surgery (SWEDEGRAFT) : Rationale and design of a multicenter, prospective, registry-based randomized clinical trial. / Ragnarsson, Sigurdur; Janiec, Mikael; Modrau, Ivy Susanne; Dreifaldt, Mats; Ericsson, Anders; Holmgren, Anders; Hultkvist, Henrik; Jeppsson, Anders; Sartipy, Ulrik; Ternström, Lisa; Per Vikholm, M. D.; de Souza, Domingos; James, Stefan; Thelin, Stefan.

In: American Heart Journal, Vol. 224, 06.2020, p. 17-24.

Research output: Contribution to journalArticle

Harvard

Ragnarsson, S, Janiec, M, Modrau, IS, Dreifaldt, M, Ericsson, A, Holmgren, A, Hultkvist, H, Jeppsson, A, Sartipy, U, Ternström, L, Per Vikholm, MD, de Souza, D, James, S & Thelin, S 2020, 'No-touch saphenous vein grafts in coronary artery surgery (SWEDEGRAFT): Rationale and design of a multicenter, prospective, registry-based randomized clinical trial', American Heart Journal, vol. 224, pp. 17-24. https://doi.org/10.1016/j.ahj.2020.03.009

APA

CBE

Ragnarsson S, Janiec M, Modrau IS, Dreifaldt M, Ericsson A, Holmgren A, Hultkvist H, Jeppsson A, Sartipy U, Ternström L, Per Vikholm MD, de Souza D, James S, Thelin S. 2020. No-touch saphenous vein grafts in coronary artery surgery (SWEDEGRAFT): Rationale and design of a multicenter, prospective, registry-based randomized clinical trial. American Heart Journal. 224:17-24. https://doi.org/10.1016/j.ahj.2020.03.009

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Ragnarsson, Sigurdur ; Janiec, Mikael ; Modrau, Ivy Susanne ; Dreifaldt, Mats ; Ericsson, Anders ; Holmgren, Anders ; Hultkvist, Henrik ; Jeppsson, Anders ; Sartipy, Ulrik ; Ternström, Lisa ; Per Vikholm, M. D. ; de Souza, Domingos ; James, Stefan ; Thelin, Stefan. / No-touch saphenous vein grafts in coronary artery surgery (SWEDEGRAFT) : Rationale and design of a multicenter, prospective, registry-based randomized clinical trial. In: American Heart Journal. 2020 ; Vol. 224. pp. 17-24.

RIS

TY - JOUR

T1 - No-touch saphenous vein grafts in coronary artery surgery (SWEDEGRAFT)

T2 - Rationale and design of a multicenter, prospective, registry-based randomized clinical trial

AU - Ragnarsson, Sigurdur

AU - Janiec, Mikael

AU - Modrau, Ivy Susanne

AU - Dreifaldt, Mats

AU - Ericsson, Anders

AU - Holmgren, Anders

AU - Hultkvist, Henrik

AU - Jeppsson, Anders

AU - Sartipy, Ulrik

AU - Ternström, Lisa

AU - Per Vikholm, M. D.

AU - de Souza, Domingos

AU - James, Stefan

AU - Thelin, Stefan

PY - 2020/6

Y1 - 2020/6

N2 - The SWEDEGRAFT study (ClinicalTrials.gov Identifier: NCT03501303) tests the hypothesis that saphenous vein grafts (SVGs) harvested with the “no-touch” technique improves patency of coronary artery bypass grafts compared with the conventional open skeletonized technique. This article describes the rationale and design of the randomized trial and baseline characteristics of the population enrolled during the first 9 months of enrollment. The SWEDEGRAFT study is a prospective, binational multicenter, open-label, registry-based trial in patients undergoing first isolated nonemergent coronary artery bypass grafting (CABG), randomized 1:1 to no-touch or conventional open skeletonized vein harvesting technique, with a planned enrollment of 900 patients. The primary end point is the proportion of patients with graft failure defined as SVGs occluded or stenosed >50% on coronary computed tomography angiography at 2 years after CABG, earlier clinically driven coronary angiography demonstrating an occluded or stenosed >50% vein graft, or death within 2 years. High-quality health registries and coronary computed tomography angiography are used to assess the primary end point. The secondary end points include wound healing in the vein graft sites and the composite outcome of major adverse cardiac events during the first 2 years based on registry data. Demographics of the first 200 patients enrolled in the trial and other CABG patients operated in Sweden during the same time period are comparable when the exclusion criteria are taken into consideration. RCT# NCT03501303

AB - The SWEDEGRAFT study (ClinicalTrials.gov Identifier: NCT03501303) tests the hypothesis that saphenous vein grafts (SVGs) harvested with the “no-touch” technique improves patency of coronary artery bypass grafts compared with the conventional open skeletonized technique. This article describes the rationale and design of the randomized trial and baseline characteristics of the population enrolled during the first 9 months of enrollment. The SWEDEGRAFT study is a prospective, binational multicenter, open-label, registry-based trial in patients undergoing first isolated nonemergent coronary artery bypass grafting (CABG), randomized 1:1 to no-touch or conventional open skeletonized vein harvesting technique, with a planned enrollment of 900 patients. The primary end point is the proportion of patients with graft failure defined as SVGs occluded or stenosed >50% on coronary computed tomography angiography at 2 years after CABG, earlier clinically driven coronary angiography demonstrating an occluded or stenosed >50% vein graft, or death within 2 years. High-quality health registries and coronary computed tomography angiography are used to assess the primary end point. The secondary end points include wound healing in the vein graft sites and the composite outcome of major adverse cardiac events during the first 2 years based on registry data. Demographics of the first 200 patients enrolled in the trial and other CABG patients operated in Sweden during the same time period are comparable when the exclusion criteria are taken into consideration. RCT# NCT03501303

UR - http://www.scopus.com/inward/record.url?scp=85082662443&partnerID=8YFLogxK

U2 - 10.1016/j.ahj.2020.03.009

DO - 10.1016/j.ahj.2020.03.009

M3 - Article

VL - 224

SP - 17

EP - 24

JO - American Heart Journal

JF - American Heart Journal

SN - 1097-6744

ER -