Nouvelle cuisine: platelets served with inflammation

Research output: Contribution to journalArticle

Abstract

Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.

Details

Authors
External organisations
  • University of Toronto
Research areas and keywords

Keywords

  • Animals, Blood Platelets, CD40 Ligand, Cell-Derived Microparticles, Cytokines, Histocompatibility Antigens Class I, Host-Pathogen Interactions, Humans, Inflammation, Thrombocytopenia, Toll-Like Receptors, Transcriptome, Journal Article, Research Support, Non-U.S. Gov't, Review
Original languageEnglish
Pages (from-to)5579-87
Number of pages9
JournalJournal of Immunology
Volume194
Issue number12
Publication statusPublished - 2015 Jun 15
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes