Novel aspects of vitamin C: how important is glypican-1 recycling?
Research output: Contribution to journal › Review article
The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Trends in Molecular Medicine|
|Publication status||Published - 2007|
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