Novel aspects of vitamin C: how important is glypican-1 recycling?

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Abstract

The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.

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  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)143-149
JournalTrends in Molecular Medicine
Volume13
Issue number4
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

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