Novel distribution of the secretory leucocyte proteinase inhibitor in kidney

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Novel distribution of the secretory leucocyte proteinase inhibitor in kidney. / Ohlsson, Sophie; Ljungkrantz, Irena; Ohlsson, Kjell; Segelmark, Mårten; Wieslander, Jörgen.

In: Mediators of Inflammation, Vol. 10, No. 6, 2001, p. 347-350.

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Ohlsson, Sophie ; Ljungkrantz, Irena ; Ohlsson, Kjell ; Segelmark, Mårten ; Wieslander, Jörgen. / Novel distribution of the secretory leucocyte proteinase inhibitor in kidney. In: Mediators of Inflammation. 2001 ; Vol. 10, No. 6. pp. 347-350.

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TY - JOUR

T1 - Novel distribution of the secretory leucocyte proteinase inhibitor in kidney

AU - Ohlsson, Sophie

AU - Ljungkrantz, Irena

AU - Ohlsson, Kjell

AU - Segelmark, Mårten

AU - Wieslander, Jörgen

PY - 2001

Y1 - 2001

N2 - The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in renal tubuli cells.

AB - The secretory leucocyte proteinase inhibitor (SLPI) is a low molecular weight, tissue-specific inhibitor of, for example, elastase and cathepsin G, which also have antimicrobial capacity. SLPI has been localised to the respiratory, gastrointestinal and genital tracts, but so far not to the kidney. The presence of SLPI in renal tubuli cells was demonstrated using immunohistochemistry and, by means of in situ hybridisation on human renal biopsies, we were able to demonstrate SLPI production. In various inflammatory conditions in the kidneys, the protease-antiprotease balance is disturbed. For this reason, as well as the possible role in the defence against ascending urinary tract infections, it is interesting to establish a source of SLPI in renal tubuli cells.

KW - Glomerulonephritis

KW - Kidney

KW - Protease inhibitor

KW - SLPI

KW - Anti-leukoprotease

U2 - 10.1080/09629350120102389

DO - 10.1080/09629350120102389

M3 - Article

VL - 10

SP - 347

EP - 350

JO - Mediators of Inflammation

JF - Mediators of Inflammation

SN - 0962-9351

IS - 6

ER -