Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction

Research output: Contribution to journalArticle

Abstract

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.

Details

Authors
  • Sabin Llona-Minguez
  • Adam Throup
  • Emilie Steiner
  • Molly Lightowler
  • Sandra Van der Haegen
  • Evert Homan
  • Lars Eriksson
  • Pål Stenmark
  • Annika Jenmalm-Jensen
  • Thomas Helleday
External organisations
  • Stockholm University
Original languageEnglish
Pages (from-to)7758-7764
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number37
Publication statusPublished - 2017 Sep 26
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes