On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

Research output: Contribution to journalArticle

Abstract

We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 pin in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands. (c) 2007 Elsevier B.V. All rights reserved.

Details

Authors
  • J. Lekki
  • Z. Stachura
  • W. Dabros
  • J. Stachura
  • F. Menzel
  • T. Reinert
  • T. Butz
  • Jan Pallon
  • E. Gontier
  • M. D. Ynsa
  • P. Moretto
  • Z. Kertesz
  • Z. Szikszai
  • A. Z. Kiss
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Subatomic Physics

Keywords

  • ion microprobe, skin penetration, titanium dioxide, nanoparticles, autoradiography
Original languageEnglish
Pages (from-to)174-177
JournalNuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume260
Issue number1
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)