On the molecular interactions in lipid bilayer-water assemblies of different curvatures

Research output: Contribution to journal › Article

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On the molecular interactions in lipid bilayer-water assemblies of different curvatures. / Talaikis, Martynas; Valldeperas, Maria; MatulaitieneÌ, Ieva; Borzova, Jekaterina Latynis; Barauskas, Justas; Niaura, Gediminas; Nylander, Tommy.

In: Journal of Physical Chemistry B, Vol. 123, No. 12, 2019, p. 2662–2672.

Research output: Contribution to journal › Article

Harvard

Talaikis, M, Valldeperas, M, MatulaitieneÌ, I, Borzova, JL, Barauskas, J, Niaura, G & Nylander, T 2019, 'On the molecular interactions in lipid bilayer-water assemblies of different curvatures', Journal of Physical Chemistry B, vol. 123, no. 12, pp. 2662–2672. https://doi.org/10.1021/acs.jpcb.8b11387

APA

Talaikis, M., Valldeperas, M., MatulaitieneÌ, I., Borzova, J. L., Barauskas, J., Niaura, G., & Nylander, T. (2019). On the molecular interactions in lipid bilayer-water assemblies of different curvatures. Journal of Physical Chemistry B, 123(12), 2662–2672. https://doi.org/10.1021/acs.jpcb.8b11387

CBE

Talaikis M, Valldeperas M, MatulaitieneÌ I, Borzova JL, Barauskas J, Niaura G, Nylander T. 2019. On the molecular interactions in lipid bilayer-water assemblies of different curvatures. Journal of Physical Chemistry B. 123(12):2662–2672. https://doi.org/10.1021/acs.jpcb.8b11387

MLA

Talaikis, Martynas et al. "On the molecular interactions in lipid bilayer-water assemblies of different curvatures". Journal of Physical Chemistry B. 2019, 123(12). 2662–2672. https://doi.org/10.1021/acs.jpcb.8b11387

Vancouver

Talaikis M, Valldeperas M, MatulaitieneÌ I, Borzova JL, Barauskas J, Niaura G et al. On the molecular interactions in lipid bilayer-water assemblies of different curvatures. Journal of Physical Chemistry B. 2019;123(12):2662–2672. https://doi.org/10.1021/acs.jpcb.8b11387

Author

Talaikis, Martynas ; Valldeperas, Maria ; MatulaitieneÌ, Ieva ; Borzova, Jekaterina Latynis ; Barauskas, Justas ; Niaura, Gediminas ; Nylander, Tommy. / On the molecular interactions in lipid bilayer-water assemblies of different curvatures. In: Journal of Physical Chemistry B. 2019 ; Vol. 123, No. 12. pp. 2662–2672.

RIS

TY - JOUR

T1 - On the molecular interactions in lipid bilayer-water assemblies of different curvatures

AU - Talaikis, Martynas

AU - Valldeperas, Maria

AU - MatulaitieneÌ, Ieva

AU - Borzova, Jekaterina Latynis

AU - Barauskas, Justas

AU - Niaura, Gediminas

AU - Nylander, Tommy

PY - 2019

Y1 - 2019

N2 - This work concerns the importance of intermolecular interactions present in aqueous lipid assembly systems depending on the type of aggregates they form. We have studied aqueous mixtures of diglycerol monooleate, Capmul glycerol monoleate (GMO-50) and polyoxyethylene (20) sorbitan monooleate (Polysorbate 80, P80) using small-angle X-ray scattering (SAXS) measurements to reveal the structure of liquid crystalline phases. On the basis of the SAXS data, a phase diagram was constructed. We discuss the effect of curvature changes of the lipid-aqueous interface obtained by changing the water content and the temperature. The results are related to the intermolecular interactions, as revealed by Raman spectroscopy, with a focus on the bilayer type of system of different curvature and bilayer flexibility, namely, the lamellar phase, bicontinuous cubic phase, and sponge phase. All phases show large similarities in their chain conformation and head group interactions as revealed by the Raman spectra, arising from the fact that all three structures are formed by lipid bilayers. However, subtle differences in the molecular organization of the sponge phase were revealed by employing Raman difference spectroscopy and by analysis of key spectroscopic indicators, which show a less dense hydrocarbon chain packing compared to the inverse bicontinuous cubic or lamellar phase.

AB - This work concerns the importance of intermolecular interactions present in aqueous lipid assembly systems depending on the type of aggregates they form. We have studied aqueous mixtures of diglycerol monooleate, Capmul glycerol monoleate (GMO-50) and polyoxyethylene (20) sorbitan monooleate (Polysorbate 80, P80) using small-angle X-ray scattering (SAXS) measurements to reveal the structure of liquid crystalline phases. On the basis of the SAXS data, a phase diagram was constructed. We discuss the effect of curvature changes of the lipid-aqueous interface obtained by changing the water content and the temperature. The results are related to the intermolecular interactions, as revealed by Raman spectroscopy, with a focus on the bilayer type of system of different curvature and bilayer flexibility, namely, the lamellar phase, bicontinuous cubic phase, and sponge phase. All phases show large similarities in their chain conformation and head group interactions as revealed by the Raman spectra, arising from the fact that all three structures are formed by lipid bilayers. However, subtle differences in the molecular organization of the sponge phase were revealed by employing Raman difference spectroscopy and by analysis of key spectroscopic indicators, which show a less dense hydrocarbon chain packing compared to the inverse bicontinuous cubic or lamellar phase.

U2 - 10.1021/acs.jpcb.8b11387

DO - 10.1021/acs.jpcb.8b11387

M3 - Article

C2 - 30785750

AN - SCOPUS:85063161018

VL - 123

SP - 2662

EP - 2672

JO - The Journal of Physical Chemistry Part B

JF - The Journal of Physical Chemistry Part B

SN - 1520-5207

IS - 12

ER -