On the stability of lithocholate derivative supramolecular tubules

Research output: Contribution to journalArticle


The self-assembly of a mannose-labelled bile salt derivative gives rise to a metastable nematic phase of monodisperse nanotubes in aqueous solutions that are characterized by a crystalline order. This work is addressed to study the relative stability of these tubular aggregates in order to have full control of such a system for possible applications. By using a static light scattering method we evaluate both the solubilities of the metastable nanotubes and of stable nanocrystals, demonstrating that these are remarkably lower than the critical micellar concentration of typical bile salts and other ionic conventional surfactants. A partial stability map is developed by combining solubility and calorimetry data, where a nematic nanotube phase region is highlighted below 60-65 °C.


External organisations
  • Sapienza University of Rome
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physical Chemistry
Original languageEnglish
Pages (from-to)512-517
Number of pages6
JournalRSC Advances
Issue number1
Publication statusPublished - 2017
Publication categoryResearch