One evidence base; three stories: do opioids relieve chronic breathlessness?

Research output: Contribution to journalLetter


title = "One evidence base; three stories: do opioids relieve chronic breathlessness?",
abstract = "The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 included trials) and added a risk-of-bias criterion (sample size). When re-analysed to account for crossover data, opioids decreased breathlessness (standardised mean differences -0.32; -0.18 to -0.47; I2=44.8{\%}) representing a clinically meaningful reduction of 0.8 points (0-10 numerical rating scale), consistent across meta-analyses.",
keywords = "COPD Pharmacology, Palliative Care, Perception of Asthma/Breathlessness",
author = "Magnus Ekstr{\"o}m and Sabrina Bajwah and Bland, {J. Martin} and Currow, {David C.} and Jamilla Hussain and Johnson, {Miriam J.}",
year = "2018",
doi = "10.1136/thoraxjnl-2016-209868",
language = "English",
volume = "73",
pages = "88--90",
journal = "Thorax",
issn = "1468-3296",
publisher = "BMJ Publishing Group",
number = "1",