One evidence base; three stories: do opioids relieve chronic breathlessness?

Research output: Contribution to journalLetter

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One evidence base; three stories : do opioids relieve chronic breathlessness? / Ekström, Magnus; Bajwah, Sabrina; Bland, J. Martin; Currow, David C.; Hussain, Jamilla; Johnson, Miriam J.

In: Thorax, Vol. 73, No. 1, 2018, p. 88-90.

Research output: Contribution to journalLetter

Harvard

Ekström, M, Bajwah, S, Bland, JM, Currow, DC, Hussain, J & Johnson, MJ 2018, 'One evidence base; three stories: do opioids relieve chronic breathlessness?', Thorax, vol. 73, no. 1, pp. 88-90. https://doi.org/10.1136/thoraxjnl-2016-209868

APA

Ekström, M., Bajwah, S., Bland, J. M., Currow, D. C., Hussain, J., & Johnson, M. J. (2018). One evidence base; three stories: do opioids relieve chronic breathlessness? Thorax, 73(1), 88-90. https://doi.org/10.1136/thoraxjnl-2016-209868

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MLA

Vancouver

Author

Ekström, Magnus ; Bajwah, Sabrina ; Bland, J. Martin ; Currow, David C. ; Hussain, Jamilla ; Johnson, Miriam J. / One evidence base; three stories : do opioids relieve chronic breathlessness?. In: Thorax. 2018 ; Vol. 73, No. 1. pp. 88-90.

RIS

TY - JOUR

T1 - One evidence base; three stories

T2 - Thorax

AU - Ekström, Magnus

AU - Bajwah, Sabrina

AU - Bland, J. Martin

AU - Currow, David C.

AU - Hussain, Jamilla

AU - Johnson, Miriam J.

PY - 2018

Y1 - 2018

N2 - The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 included trials) and added a risk-of-bias criterion (sample size). When re-analysed to account for crossover data, opioids decreased breathlessness (standardised mean differences -0.32; -0.18 to -0.47; I2=44.8%) representing a clinically meaningful reduction of 0.8 points (0-10 numerical rating scale), consistent across meta-analyses.

AB - The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 included trials) and added a risk-of-bias criterion (sample size). When re-analysed to account for crossover data, opioids decreased breathlessness (standardised mean differences -0.32; -0.18 to -0.47; I2=44.8%) representing a clinically meaningful reduction of 0.8 points (0-10 numerical rating scale), consistent across meta-analyses.

KW - COPD Pharmacology

KW - Palliative Care

KW - Perception of Asthma/Breathlessness

UR - http://www.scopus.com/inward/record.url?scp=85039059825&partnerID=8YFLogxK

U2 - 10.1136/thoraxjnl-2016-209868

DO - 10.1136/thoraxjnl-2016-209868

M3 - Letter

VL - 73

SP - 88

EP - 90

JO - Thorax

JF - Thorax

SN - 1468-3296

IS - 1

ER -