Optical Coherence Tomography Characterization of Coronary Lithoplasty for Treatment of Calcified Lesions: First Description

Research output: Contribution to journalArticle

Abstract

Objectives This study sought to determine the mechanistic effects of a novel balloon-based lithoplasty system on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). Background The Shockwave Coronary Rx Lithoplasty System (Shockwave Medical, Fremont, California) delivers localized, lithotripsy-enhanced disruption of calcium within the target lesion (i.e., lithoplasty) for vessel preparation before stent implantation. Methods We analyzed OCT findings in 31 patients in whom lithoplasty was used to treat severely calcified stenotic coronary lesions. Results After lithoplasty, intraplaque calcium fracture was identified in 43% of lesions, with circumferential multiple fractures noted in >25%. The frequency of calcium fractures per lesion increased in the most severely calcified plaques (highest tertile vs. lowest tertile; p = 0.009), with a trend toward greater incidence of calcium fracture (77.8% vs. 22.2%; p = 0.057). Post-lithoplasty, mean acute area gain was 2.1 mm2, which further increased with stent implantation, achieving a minimal stent area of 5.94 ± 1.98 mm2 and mean stent expansion of 112.0 ± 37.2%. Deep dissections, as part of the angioplasty effect, occurred in 13% of cases and were successfully treated with stent implantation without incidence of acute closure, slow flow/no reflow, or perforation. Conclusions High-resolution imaging by OCT delineated calcium modification with fracture as a major mechanism of action of lithoplasty in vivo and demonstrated efficacy in the achievement of significant acute area gain and favorable stent expansion.

Details

Authors
  • Ziad A. Ali
  • Todd J. Brinton
  • Jonathan M. Hill
  • Akiko Maehara
  • Mitsuaki Matsumura
  • Keyvan Karimi Galougahi
  • Uday Illindala
  • Matthias Götberg
  • Robert Whitbourn
  • Nicolas Van Mieghem
  • Ian T. Meredith
  • Carlo Di Mario
  • Jean Fajadet
Organisations
External organisations
  • King's College Hospital
  • Amsterdam UMC - Vrije Universiteit Amsterdam
  • Royal Brompton Hospital
  • Columbia University
  • Stanford University Medical Center
  • Shockwave Medical Inc.
  • St. Vincent's Hospital, Melbourne
  • Monash Medical Centre
  • Clinique Pasteur, Toulouse
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
  • Surgery

Keywords

  • calcification, coronary artery disease, intravascular imaging, optical coherence tomography
Original languageEnglish
Pages (from-to)897-906
Number of pages10
JournalJACC: Cardiovascular Imaging
Volume10
Issue number8
Publication statusPublished - 2017 Aug 1
Publication categoryResearch
Peer-reviewedYes