Optimising islet engraftment is critical for successful clinical islet transplantation

Research output: Contribution to journalArticle

Abstract

Clinical islet transplantation is currently being explored as a treatment for persons with type 1 diabetes and hypoglycaemia unawareness. Although 'proof-of-principle' has been established in recent clinical studies, the procedure suffers from low efficacy. At the time of transplantation, the isolated islets are allowed to embolise the liver after injection in the portal vein, a procedure that is unique in the area of transplantation. A novel view on the engraftment of intraportally transplanted islets is presented that could explain the low efficacy of the procedure.

Details

Authors
  • O Korsgren
  • T Lundgren
  • M Felldin
  • A Foss
  • B Isaksson
  • J Permert
  • N H Persson
  • E Rafael
  • M Ryden
  • K Salmela
  • A Tibell
  • G Tufveson
  • B Nilsson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • tumour metastasis, revascularisation, thrombosis, liver morphology, islet transplantation, intramuscular, intraportal, innate immunity, clinical, engraftment
Original languageEnglish
Pages (from-to)227-232
JournalDiabetologia
Volume51
Issue number2
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes