Optimization of integrated chromatography sequences for purification of biopharmaceuticals
Research output: Contribution to journal › Article
With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itself is a versatile tool to be used in downstream design which is demonstrated in two case studies: a four-column integrated sequence and a continuously loaded twin-capture setup with five columns.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Early online date||2019 Jun 17|
|Publication status||Published - 2019 Nov|