Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.

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Abstract

The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.

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  • Medical Engineering
Original languageEnglish
Pages (from-to)3143-3150
JournalElectrophoresis
Volume33
Issue number21
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes