Optimizing the friability of a tablet formulation

Research output: Contribution to journalArticle

Abstract

The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Probability Theory and Statistics
Original languageEnglish
Pages (from-to)1063-1067
JournalDrug Development and Industrial Pharmacy
Volume13
Issue number6
Publication statusPublished - 1987
Publication categoryResearch
Peer-reviewedYes