Optimizing the friability of a tablet formulation
Research output: Contribution to journal › Article
The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Drug Development and Industrial Pharmacy|
|Publication status||Published - 1987|