Ornithine decarboxylase and S-adenosylmethionine decarboxylase in trypanosomatids.

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Abstract

The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (Trypanosoma cruzi), cutaneous (lesihmania spp.) and visceral ((eishmania donovani) leishmaniasis. The metabolism of polyamines in the parasites is a potential target for the development of new drugs for treatment of these diseases. The key steps in polyamine synthesis are catalysed by ODC (ornithine decarboxylase) and AdoMetDC (S-adenosylmethionine decarboxylase). In the present paper, some of the available information on ODC and AdoMetDC in trypanosomatids will be described and discussed.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biochemistry and Molecular Biology

Keywords

  • drug target, decarboxylase, ornithine decarboxylase (ODC), polyamine, protozoan parasite, S-adenosylmethionine
Original languageEnglish
Pages (from-to)314-317
JournalBiochemical Society Transactions
Volume35
Issue numberPt 2
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes