Orthostatic hypotension in organic dementia: relationship between blood pressure, cortical blood flow and symptoms

Research output: Contribution to journalArticle

Abstract

Regional cerebral blood flow was measured in 35 patients with organic dementia (Alzheimer's disease, n = 13, vascular dementia, n = 17, frontotemporal dementia, n = 5) and orthostatic hypotension. Measurements were performed during supine rest and during head-up tilt (60 degrees). Despite marked blood pressure falls, few patients had symptoms of orthostatic hypotension. All three dementia groups had a decrease in regional cerebral blood flow in the frontal lobes during head-up tilt, but no change in mean hemispheric flow. All patients had a consistent drop in their systolic blood pressure upon head-up tilt, with a wide variation over time. The findings suggest that orthostatic hypotension needs to be considered, and actively sought for, in organic dementia as many patients may lack the typical symptoms of orthostatic hypotension, despite a marked fall in blood pressure.

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Subject classification (UKÄ) – MANDATORY

  • Medical and Health Sciences
Original languageEnglish
Pages (from-to)29-36
JournalClinical autonomic research : official journal of the Clinical Autonomic Research Society
Volume6
Issue number1
Publication statusPublished - 1996
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Faculty of Medicine (000022000), Department of Child and Youth Psychiatry (013303003), Clinical Memory Research Unit (013242610), Medicine (Lund) (013230025), Department of Psychogeriatrics (013304000)