Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

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Abstract

Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate the role of osteoblasts (OBLs) and OCLs in the HSC niche formation. The absence of OCL activity resulted in a defective HSC niche associated with an increased proportion of mesenchymal progenitors but reduced osteoblastic differentiation, leading to impaired HSC homing to the BM. Restoration of OCL activity reversed the defect in HSC niche formation. Our data demonstrate that OBLs are required for establishing HSC niches and that osteoblastic development is induced by OCLs. These findings broaden our knowledge of the HSC niche formation, which is critical for understanding normal and pathological hematopoiesis.

Details

Authors
  • Anna Mansour
  • Grazia Abou-Ezzi
  • Ewa Sitnicka Quinn
  • Sten Eirik W Jacobsen
  • Abdelilah Wakkach
  • Claudine Blin-Wakkach
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)537-549
JournalJournal of Experimental Medicine
Volume209
Issue number3
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes

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