Osteolytic potential of triphenyl bismuth as an alternative contrast medium in acrylic bone cement

Research output: Contribution to journalArticle


Radiopaque cement containing barium sulfate causes significantly more bone resorption in vivo and in vitro than radiolucent cement. The aim of this study was to investigate the osteolytic potential of an alternative radiopaque agent, triphenyl bismuth (TPB). Bone cement particles containing various concentration of TPB (15 and 25 wt%) prepared by two methods, blending and dissolution, were added to monocytes in a bone resorption assay and the extent of lacunar resorption on dentine slices was determined. The results clearly show that cement particles containing TPB cause less bone resorption than cement particles containing barium sulfate. In addition, our results suggest that TPB prepared by dissolution in bone cement induces less osteolytic response than TPB-cement prepared by blending. The osteolysis in response to bone cement wear particles may therefore be reduced with TPB prepared using the blending technique.


  • H Xu
  • Saba Abdulghani
  • J Behiri
  • A Sabokbar
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Orthopedics


  • triphenyl bismuth, radiopacity, bone cement, bone resorption, osteoclast
Original languageEnglish
Pages (from-to)64-73
JournalJournal of Biomedical Materials Research. Part B - Applied Biomaterials
Issue number1
Publication statusPublished - 2005
Publication categoryResearch