Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.

Research output: Contribution to journalArticle

Abstract

Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.

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Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy
Original languageEnglish
Pages (from-to)58-67
JournalAllergy
Volume71
Issue number1
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes

Related research output

Anele Gela, 2016, Lund: Lund University: Faculty of Medicine. 64 p.

Research output: ThesisDoctoral Thesis (compilation)

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