Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.
Research output: Contribution to journal › Article
Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Publication status||Published - 2016|
Related research output
Anele Gela, 2016, Lund: Lund University: Faculty of Medicine. 64 p.
Research output: Thesis › Doctoral Thesis (compilation)