Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy

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Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy. / Mellstrom, D; Johansson, C; Johnell, Olof; Lindstedt, G; Lundberg, P A; Obrant, Karl; Schoon, I M; Toss, G; Ytterberg, B O.

In: Calcified Tissue International, Vol. 53, No. 6, 1993, p. 370-377.

Research output: Contribution to journalArticle

Harvard

Mellstrom, D, Johansson, C, Johnell, O, Lindstedt, G, Lundberg, PA, Obrant, K, Schoon, IM, Toss, G & Ytterberg, BO 1993, 'Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy', Calcified Tissue International, vol. 53, no. 6, pp. 370-377.

APA

Mellstrom, D., Johansson, C., Johnell, O., Lindstedt, G., Lundberg, P. A., Obrant, K., Schoon, I. M., Toss, G., & Ytterberg, B. O. (1993). Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy. Calcified Tissue International, 53(6), 370-377.

CBE

Mellstrom D, Johansson C, Johnell O, Lindstedt G, Lundberg PA, Obrant K, Schoon IM, Toss G, Ytterberg BO. 1993. Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy. Calcified Tissue International. 53(6):370-377.

MLA

Vancouver

Mellstrom D, Johansson C, Johnell O, Lindstedt G, Lundberg PA, Obrant K et al. Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy. Calcified Tissue International. 1993;53(6):370-377.

Author

Mellstrom, D ; Johansson, C ; Johnell, Olof ; Lindstedt, G ; Lundberg, P A ; Obrant, Karl ; Schoon, I M ; Toss, G ; Ytterberg, B O. / Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy. In: Calcified Tissue International. 1993 ; Vol. 53, No. 6. pp. 370-377.

RIS

TY - JOUR

T1 - Osteoporosis, metabolic aberrations, and increased risk for vertebral fractures after partial gastrectomy

AU - Mellstrom, D

AU - Johansson, C

AU - Johnell, Olof

AU - Lindstedt, G

AU - Lundberg, P A

AU - Obrant, Karl

AU - Schoon, I M

AU - Toss, G

AU - Ytterberg, B O

PY - 1993

Y1 - 1993

N2 - A case-control study compared 129 men with earlier partial gastrectomy (operation during the period 1952-1961) with 216 men from a community-based population study. All were born 1910-1915 and the mean age was 72 years. Men with a previous partial gastrectomy had vertebral fractures in 19% compared with 4% (P < 0.01) in the control population. Bone mineral density (BMD) in the right calcaneus measured with dual energy photon absorptiometry was 20% lower in men with a Billroth II operation (P < 0.001) and 8% lower with a Billroth I operation (ns). In comparison with the controls, the men subjected to partial gastrectomy had higher serum concentrations of osteocalcin and alkaline phosphatase activity, a lower serum concentration of 25-hydroxyvitamin D (25OHD) and a lower body mass index (BMI). There were no difference in serum concentrations of free calcium, intact parathyroid hormone (PTH), or free thyroxine. The smoking prevalence was significantly higher in men with partial gastrectomy than in controls. Smokers had significantly lower serum concentrations of intact PTH and 25OHD than nonsmokers and also lower BMD and BMI. The relationships between intact PTH on one hand, and ionized calcium (inverse relationship) and osteocalcin (direct relationship) on the other were preserved in smokers, however. Gastroscopy was performed in 78 men with multiple biopsies in the gastric remnant and also in the small intestine. All but two subjects had chronic gastritis. Examination of sternal bone marrow smears showed that 40% of the Billroth-operated men lacked bone marrow reticular iron.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - A case-control study compared 129 men with earlier partial gastrectomy (operation during the period 1952-1961) with 216 men from a community-based population study. All were born 1910-1915 and the mean age was 72 years. Men with a previous partial gastrectomy had vertebral fractures in 19% compared with 4% (P < 0.01) in the control population. Bone mineral density (BMD) in the right calcaneus measured with dual energy photon absorptiometry was 20% lower in men with a Billroth II operation (P < 0.001) and 8% lower with a Billroth I operation (ns). In comparison with the controls, the men subjected to partial gastrectomy had higher serum concentrations of osteocalcin and alkaline phosphatase activity, a lower serum concentration of 25-hydroxyvitamin D (25OHD) and a lower body mass index (BMI). There were no difference in serum concentrations of free calcium, intact parathyroid hormone (PTH), or free thyroxine. The smoking prevalence was significantly higher in men with partial gastrectomy than in controls. Smokers had significantly lower serum concentrations of intact PTH and 25OHD than nonsmokers and also lower BMD and BMI. The relationships between intact PTH on one hand, and ionized calcium (inverse relationship) and osteocalcin (direct relationship) on the other were preserved in smokers, however. Gastroscopy was performed in 78 men with multiple biopsies in the gastric remnant and also in the small intestine. All but two subjects had chronic gastritis. Examination of sternal bone marrow smears showed that 40% of the Billroth-operated men lacked bone marrow reticular iron.(ABSTRACT TRUNCATED AT 250 WORDS)

M3 - Article

VL - 53

SP - 370

EP - 377

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 1432-0827

IS - 6

ER -