Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA)

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Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device : Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA). / Ammirati, Enrico; Brambatti, Michela; Braun, Oscar; Shah, Palak; Cipriani, Manlio; Bui, Quan M.; Veenis, Jesse; Lee, Euyhyun; Xu, Ronghui; Hong, Kimberly N.; Van de Heyning, Caroline M.; Perna, Enrico; Timmermans, Philippe; Cikes, Maja; Brugts, Jasper J.; Veronese, Giacomo; Minto, Jonathan; Smith, Saige; Gjesdal, Grunde; Gernhofer, Yan K.; Partida, Cynthia; Potena, Luciano; Masetti, Marco; Boschi, Silvia; Loforte, Antonio; Jakus, Nina; Milicic, Davor; Nilsson, Johan; De Bock, Dina; Sterken, Caroline; Van den Bossche, Klaartje; Rega, Filip; Tran, Hao; Singh, Ramesh; Montomoli, Jonathan; Mondino, Michele; Greenberg, Barry; Russo, Claudio F.; Pretorius, Victor; Liviu, Klein; Frigerio, Maria; Adler, Eric D.

In: International Journal of Cardiology, Vol. 324, 2021.

Research output: Contribution to journalArticle

Harvard

Ammirati, E, Brambatti, M, Braun, O, Shah, P, Cipriani, M, Bui, QM, Veenis, J, Lee, E, Xu, R, Hong, KN, Van de Heyning, CM, Perna, E, Timmermans, P, Cikes, M, Brugts, JJ, Veronese, G, Minto, J, Smith, S, Gjesdal, G, Gernhofer, YK, Partida, C, Potena, L, Masetti, M, Boschi, S, Loforte, A, Jakus, N, Milicic, D, Nilsson, J, De Bock, D, Sterken, C, Van den Bossche, K, Rega, F, Tran, H, Singh, R, Montomoli, J, Mondino, M, Greenberg, B, Russo, CF, Pretorius, V, Liviu, K, Frigerio, M & Adler, ED 2021, 'Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA)', International Journal of Cardiology, vol. 324. https://doi.org/10.1016/j.ijcard.2020.09.026

APA

Ammirati, E., Brambatti, M., Braun, O., Shah, P., Cipriani, M., Bui, Q. M., Veenis, J., Lee, E., Xu, R., Hong, K. N., Van de Heyning, C. M., Perna, E., Timmermans, P., Cikes, M., Brugts, J. J., Veronese, G., Minto, J., Smith, S., Gjesdal, G., ... Adler, E. D. (2021). Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA). International Journal of Cardiology, 324. https://doi.org/10.1016/j.ijcard.2020.09.026

CBE

Ammirati E, Brambatti M, Braun O, Shah P, Cipriani M, Bui QM, Veenis J, Lee E, Xu R, Hong KN, Van de Heyning CM, Perna E, Timmermans P, Cikes M, Brugts JJ, Veronese G, Minto J, Smith S, Gjesdal G, Gernhofer YK, Partida C, Potena L, Masetti M, Boschi S, Loforte A, Jakus N, Milicic D, Nilsson J, De Bock D, Sterken C, Van den Bossche K, Rega F, Tran H, Singh R, Montomoli J, Mondino M, Greenberg B, Russo CF, Pretorius V, Liviu K, Frigerio M, Adler ED. 2021. Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA). International Journal of Cardiology. 324. https://doi.org/10.1016/j.ijcard.2020.09.026

MLA

Vancouver

Author

Ammirati, Enrico ; Brambatti, Michela ; Braun, Oscar ; Shah, Palak ; Cipriani, Manlio ; Bui, Quan M. ; Veenis, Jesse ; Lee, Euyhyun ; Xu, Ronghui ; Hong, Kimberly N. ; Van de Heyning, Caroline M. ; Perna, Enrico ; Timmermans, Philippe ; Cikes, Maja ; Brugts, Jasper J. ; Veronese, Giacomo ; Minto, Jonathan ; Smith, Saige ; Gjesdal, Grunde ; Gernhofer, Yan K. ; Partida, Cynthia ; Potena, Luciano ; Masetti, Marco ; Boschi, Silvia ; Loforte, Antonio ; Jakus, Nina ; Milicic, Davor ; Nilsson, Johan ; De Bock, Dina ; Sterken, Caroline ; Van den Bossche, Klaartje ; Rega, Filip ; Tran, Hao ; Singh, Ramesh ; Montomoli, Jonathan ; Mondino, Michele ; Greenberg, Barry ; Russo, Claudio F. ; Pretorius, Victor ; Liviu, Klein ; Frigerio, Maria ; Adler, Eric D. / Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device : Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA). In: International Journal of Cardiology. 2021 ; Vol. 324.

RIS

TY - JOUR

T1 - Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device

T2 - Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA)

AU - Ammirati, Enrico

AU - Brambatti, Michela

AU - Braun, Oscar

AU - Shah, Palak

AU - Cipriani, Manlio

AU - Bui, Quan M.

AU - Veenis, Jesse

AU - Lee, Euyhyun

AU - Xu, Ronghui

AU - Hong, Kimberly N.

AU - Van de Heyning, Caroline M.

AU - Perna, Enrico

AU - Timmermans, Philippe

AU - Cikes, Maja

AU - Brugts, Jasper J.

AU - Veronese, Giacomo

AU - Minto, Jonathan

AU - Smith, Saige

AU - Gjesdal, Grunde

AU - Gernhofer, Yan K.

AU - Partida, Cynthia

AU - Potena, Luciano

AU - Masetti, Marco

AU - Boschi, Silvia

AU - Loforte, Antonio

AU - Jakus, Nina

AU - Milicic, Davor

AU - Nilsson, Johan

AU - De Bock, Dina

AU - Sterken, Caroline

AU - Van den Bossche, Klaartje

AU - Rega, Filip

AU - Tran, Hao

AU - Singh, Ramesh

AU - Montomoli, Jonathan

AU - Mondino, Michele

AU - Greenberg, Barry

AU - Russo, Claudio F.

AU - Pretorius, Victor

AU - Liviu, Klein

AU - Frigerio, Maria

AU - Adler, Eric D.

PY - 2021

Y1 - 2021

N2 - Background: Geographic variations in management and outcomes of individuals supported by continuous-flow left ventricular assist devices (CF-LVAD) between the United States (US) and Europe (EU) is largely unknown. Methods: We created a retrospective, multinational registry of 524 patients who received a CF-LVAD (either HVAD or Heartmate II) between January 2008 and April 2017. Follow up spanned from date of CF-LVAD implant to post-HTx period with a median follow up of 44.8 months. Results: The cohort included 299 (57.1%) EU and 225 (42.9%) US patients. Although the US cohort was significantly older with a higher prevalence of comorbidities, survival was similar between the cohorts (US 63.1%, EU 68.4% at 5 years, unadjusted log-rank test p = 0.43).Multivariate analyses suggested that older age, higher body mass index, elevated creatinine, use of temporary mechanical circulatory support prior CF-LVAD, and implantation of HVAD were associated with increased mortality. Among CF-LVAD patients undergoing HTx, the median time on CF-LVAD support was shorter in the US, meanwhile US donors were younger. Finally, the pattern of adverse events (stroke, gastrointestinal bleedings, late right ventricular failure, and driveline infection) during support differed significantly between US and EU. Conclusions: Although waitlisted patients in the US on CF-LVAD have higher risk comorbid conditions, the overall outcome is similar in US and EU. Geographic variations with regards to donor characteristics, duration of CF-LVAD support prior to transplant, and adverse events on support can explain the disparity in the utilization of mechanical bridge to transplant strategy between US and EU.

AB - Background: Geographic variations in management and outcomes of individuals supported by continuous-flow left ventricular assist devices (CF-LVAD) between the United States (US) and Europe (EU) is largely unknown. Methods: We created a retrospective, multinational registry of 524 patients who received a CF-LVAD (either HVAD or Heartmate II) between January 2008 and April 2017. Follow up spanned from date of CF-LVAD implant to post-HTx period with a median follow up of 44.8 months. Results: The cohort included 299 (57.1%) EU and 225 (42.9%) US patients. Although the US cohort was significantly older with a higher prevalence of comorbidities, survival was similar between the cohorts (US 63.1%, EU 68.4% at 5 years, unadjusted log-rank test p = 0.43).Multivariate analyses suggested that older age, higher body mass index, elevated creatinine, use of temporary mechanical circulatory support prior CF-LVAD, and implantation of HVAD were associated with increased mortality. Among CF-LVAD patients undergoing HTx, the median time on CF-LVAD support was shorter in the US, meanwhile US donors were younger. Finally, the pattern of adverse events (stroke, gastrointestinal bleedings, late right ventricular failure, and driveline infection) during support differed significantly between US and EU. Conclusions: Although waitlisted patients in the US on CF-LVAD have higher risk comorbid conditions, the overall outcome is similar in US and EU. Geographic variations with regards to donor characteristics, duration of CF-LVAD support prior to transplant, and adverse events on support can explain the disparity in the utilization of mechanical bridge to transplant strategy between US and EU.

KW - Bridge to transplantation

KW - Continuous flow left ventricular assist device

KW - Donor heart

KW - Heart transplant list

KW - Heart transplantation

KW - Outcome

UR - http://www.scopus.com/inward/record.url?scp=85092441388&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2020.09.026

DO - 10.1016/j.ijcard.2020.09.026

M3 - Article

C2 - 32950592

AN - SCOPUS:85092441388

VL - 324

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -