Overall cancer incidence not increased after prosthetic knee replacement: 14,551 patients followed for 66,622 person-years

Research output: Contribution to journalArticle


It is unknown whether patients as a consequence of prosthetic joint replacement are at a higher risk of developing cancer. We therefore analyzed cancer incidence following prosthetic knee replacement (TKR). The observed cancer incidence in 14,551 patients from the population-based Swedish Knee Arthroplasty Register who have undergone TKR because of osteoarthrosis (OA, n = 10,120) or rheumatoid arthritis (RA, n = 4431) were compared with the expected cancer incidence for a Swedish reference population. The cohort was followed for a total of 66,622 person-years. We followed 33% of the patients with OA and 59% of those with RA for more than 5 years. All patients who underwent TKR, whether for OA or for RA, had lower than expected total cancer incidence. We found a markedly low incidence of colorectal carcinoma, especially in patients with RA. Our results do not indicate an increased incidence of cancer following TKR.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology


  • Arthritis, Rheumatoid, Colorectal Neoplasms, Female, Humans, Knee Prosthesis, Male, Neoplasms, Osteoarthritis, Sweden, Time Factors
Original languageEnglish
Pages (from-to)30-3
Number of pages4
JournalInternational Journal of Cancer
Issue number1
Publication statusPublished - 1996 Sep 27
Publication categoryResearch