Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.

Research output: Contribution to journalArticle

Abstract

Translocation-associated gene fusions are well recognized in acute myeloid leukemia. Other molecular genetic changes are less well known. The novel cDNA technology has opened the avenue to large-scale gene expression analysis. Our aim was to perform cDNA microarray analysis of acute myeloid leukemia (AML).

Details

Authors
  • Marcelo L Larramendy
  • Tarja Niini
  • Erkki Elonen
  • Bálint Nagy
  • Juha Ollila
  • Mauno Vihinen
  • Sakari Knuutila
External organisations
  • External Organization - Unknown
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • Receptor Protein-Tyrosine Kinases: genetics, RNA: metabolism, Oncogenes: physiology, Oncogene Proteins: genetics, Nuclear Proteins: physiology, Nuclear Proteins: genetics, Neoplasm Proteins: physiology, Neoplasm Proteins: genetics, Myeloid: genetics, Leukemia, myc: physiology, myc: genetics, bcl-2: physiology, bcl-2: genetics, Genes, Gene Expression Regulation: physiology, DNA-Binding Proteins: physiology, DNA-Binding Proteins: genetics, Carrier Proteins: physiology, Carrier Proteins: genetics, Calcium-Calmodulin-Dependent Protein Kinases: genetics, Calcium-Calmodulin-Dependent Protein Kinases: physiology, Receptor Protein-Tyrosine Kinases: physiology, Receptor, Macrophage Colony-Stimulating Factor: genetics, Macrophage Colony-Stimulating Factor: physiology, Receptors, Fibroblast Growth Factor: genetics, Fibroblast Growth Factor: physiology, Viral Proteins: genetics, Viral Proteins: physiology
Original languageEnglish
Pages (from-to)569-577
JournalHaematologica
Volume87
Issue number6
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes