Oxidative activation of the propolis hapten isoprenyl caffeate

Research output: Contribution to journalArticle

Abstract

The reactions of isoprenyl caffeate, the strongest allergen known to be present in propolis, with plausible functional groups of proteins were studied. The thiols glutathione and cysteine, which add to isoprenyl caffeate after having been oxidised to the corresponding quinone, served as model substances. The structure of the thiol adducts was determined by spectroscopic methods, addition being found to occur at C-2. The results support the hypothesis that the catecholic propolis hapten is a pro-hapten that forms a complete antigen after oxidation to caffeate quinone and addition to nucleophilic groups of proteins.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Dermatology and Venereal Diseases
Original languageEnglish
Pages (from-to)34-36
JournalActa Dermato-Venereologica
Volume75
Issue number1
Publication statusPublished - 1995
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Department of Dermatology and Venereology (Lund) (013006000)