Pancreatic cancer stroma: controversies and current insights

Research output: Contribution to journalReview article

Abstract

Pancreatic cancer is characterized by a dense stromal response. The stroma includes a heterogeneous mass of cells, including pancreatic stellate cells, fibroblasts, immune cells and nerve cells, as well as extracellular matrix proteins, cytokines and growth factors, which interact with the tumor cells. Previous research has indicated that stromal elements contribute to tumor growth and aggressiveness. However, recent studies suggest that some elements of the stroma may actually restrain the tumor. This review focuses on the complex interactions between the stromal microenvironment and tumor cells, discussing molecular mechanisms and potential future diagnostic and therapeutic approaches by targeting the stroma.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • desmoplasia, microenvironment, Pancreatic cancer, stroma, targeted therapy
Original languageEnglish
Pages (from-to)641-646
JournalScandinavian Journal of Gastroenterology
Volume52
Issue number6-7
Publication statusPublished - 2017 Jul 3
Publication categoryResearch
Peer-reviewedYes